Relation among CXC chemokine receptor 16, high-sensitivity C-reactive protein and carotid plaqeues of acute cerebral infarction
Yang Sujing
Song Qing
Hao Qiuyan
Lin Ying
Yang Xiaoqin
Liu Bin
Abstract：Objective To investigate the relation among CXC chemokine receptor 16 (CXCL16),high-sensitivity C-reactive protein (hs-CRP) and carotid plaqeues of acute cerebral infarction.Methods One hundred and twenty acute cerebral infarction patients were classified into without plaque group(n =22) and plaque group(n =96) ; they were also divided into unstable plaque group (n =59) and stable plaque group(n =40).Blood samples were collected on the next day after admission.CXCL16 and hs-CRP were detected by complete automatic plasma biochemistry.The relation among CXCL16 and hs-CRP with carotid plaqeues was analyzed.Results The level of CXCL16 and hs-CRP in patients of acute cerebral infraction with carotid plaque was higher than that in patients without plaque; the level in patients with unstable plaque group was higher than that in plaque group [(2.5 ±1.0) μg/L vs(1.7 ±0.8)μg/L,(5.3 ±2.4)mg/L vs (3.7 ± 1.9)mg/L,all P ＜0.01].The level of CXCL16 and hs-CRP was in a positive correlation; area under the ROC curve of CXCL16 was larger than that of hs-CRP[(3.0 ± 1.0)μg/L vs (2.0 ±0.7) μg/L,(6.0 ±2.4)mg/L vs(4.3 ±2.0)mg/L,all P＜0.01].The area under the ROC curve of serum CXC CL 16 was 0.798,P =0.000,95％ CI:0.709-0.886 ; the area under the ROC curve of hs-CRP was 0.703,P =0.001,95％ CI:0.598-0.807.The area under the ROC curve of Serum CXC chemokine receptor 16 was greater than that of high-sensitivity C-reactive protein.Conclusion The level of CXCL16 and hs-CRP can predict carotid atherosclerosis and stability of plaqeue.
Keywords：Acute cerebral infarctionCXC chemokine receptor 16High-sensitivity C-reactive proteinCarotid plaqeues
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1599-1601 )