Clinical significance of thyroid related hormones in patients with chronic obstructive pulmonary disease
Ye Xiayun
Cheng Xiaowen
Dai Yongli
Abstract：Objective To explore clinical significance of serum levels of thyroid hormones in patients with chronic obstructive pulmonary disease(COPD).Methods Ninety-six cases of patients with COPD were divided into three groups according to the severity of disease.Serum thyroid hormone include levels of Serum triiodothyronin(TT3),tetraiodothyronin(TT4),free triiodothyronin (FT3),free tetraiodothyronin (FT4) and thyroid stimulating hormone(TSH) were measured by chemiluminescence immunoassay in 96 COPD patients and 90 healthy subjects as controls.Results TT3,TT4,TSH,FT3,FT4 in control group were (1.5 ± 0.5) nmol/L,(96 ± 36) nmol/L,(3.3 ± 1.2) mU/L,(4.4 ± 1.2) pmol/L,(16.6 ± 9.6) pmol/L,respectively ; those in COPD group were (0.7 ±0.3) nmol/L,(66 ± 33) nmol/L,(2.5 ± 1.2) mU/L,(2.1 ± 0.5) pmol/L,(12.1 ± 6.6) pmol/L; the levels of TT4,FT4,TSH of COPD were decreased compared with control group (P ＜ 0.05) ; the levels of TT3,FT3 of COPD were decreased significantly compared with control group(P ＜ 0.01).Compared with the group of remission period,the levels of TT3,FT3 of were decreased in the patients of acute period(P ＜ 0.05) ; the levels of TT3,FT3 of were decreased significantly in the cases of COPD with respiratory failure than the other cases of COPD (P ＜ 0.01).Conclusion Thyroid hormone levels might be involved in state of COPD; thyroid hormone levels can be used to assess the severity of COPD.
Keywords：Chronic obstructive pulmonary diseaseThyroxineEuthyriod sick sydrome
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1579-1581 )