Correlation between atherosclerosis markers and lower limb arterial diseases in elderly patients with hypertension
Liu Haotian
Tao Meiying
Huang Wen
Ding Hongyu
Abstract：Objective To investigate the correlation between arteriosclerosis markers and lower limb arterial diseases in elderly patients with hypertension; to provide clinical evidence for early prevention of lower limb atherosclerosis.Methods Color Doppler ultrasonography and noninvasive assessment of arteriosclerosis were measured in 88 elderly patients with hypertension.According to pulse wave velocity (baPWV) or ankle-brachial index (ABI),the patients were divided to two groups:high baPWV group (baPWV was higher than age and gender-baPWV standard curve),normal baPWV group (baPWY was lower than age and gender-baPWV standard curve),low ABI group (ABI ≤0.9) and normal ABI group (ABI ＞ 0.9).Results Compared to that in normal baPWV group,interior-medial thickness (IMT) was significantly thicker [femoral artery(1.08 ±0.16)mm vs.(0.93±0.13) mm,P＜0.01]; popliteal artery(1.02±0.16)mm vs.(0.84±0.11)mm,P＜0.01],peak systolic velocity (PSV) [femoral artery (68 ± 13)cm/s vs.(75 ± 16) em/s,P ＜0.05] ;popliteal artery (50 ± 70) cm/s vs (56 ± 11) cm/s,P ＜ 0.01],end diastolic velocity (EDV) [femoral artery (12.5 ± 2.0) cm/s vs.(19.6±2.4) cm/s,P＜0.01]; poplitealartery(10.1±2.0) cm/s vs.(14.9 ±2.7) cm/s,P＜0.01) and pulsatility index (PI) [(femoral artery,(2.3 ± 1.3) vs (3.6 ± 1.5),P ＜ 0.01 ; popliteal artery,(4.0 ± 1.9) vs (4.9 ± 2.0),P ＜ 0.05)] were significantly lower,but resistant index (RI) [femoral artery,(0.82 ± 0.23) vs (0.73 ± 0.18),P ＜ 0.05 ; popliteal artery,(0.82 ± 0.22) vs (0.73 ± 0.20),P ＜ 0.05] was significantly higher in the high baPWV group.There was a higher morbidity of lower limb arterial stenosis and more stenosis in high baPWV group than that in normal baPWV group[91.3％ (42/46) vs 76.2％ (32/42),P ＜0.01].Similarly,compared with that in normal ABI group,IMT was significantly thicker [femoral artery,(1.12 ±0.18) mm vs (0.88±0.12) mm,P＜0.01; poplitealartery,(1.10±0.17) mmvs.(0.80±0.15) mm,P＜0.01],PSV [femoral artery,(58 ± 12) em/s vs.(80± 16) em/s,P＜0.01; popliteal artery,(46±6) em/s vs.(60 ± 14) cm/s,P ＜0.01],EDV [femoral artery,(10.1 ±1.9) cm/s vs.(23.3 ±3.2) cm/s,P＜0.01 ; popliteal artery,(9.1±2.1) cm/svs.(16.2±3.2) em/s,P＜0.01] and PI [femoral artery,(2.2±1.3) vs (3.7± 1.7),P ＜ 0.01 ; popliteal artery,(3.9 ± 2.0) vs (5.0 ± 2.3),P ＜ 0.05) were significantly lower,but RI [femoral artery,(0.83 ±0.26) vs (0.71 ± 0.18),P ＜ 0.05 ; popliteal artery,(0.83 ± 0.28) vs (0.72 ± 0.21),P ＜ 0.05] was significantly higher in the low ABI group.There was a higher morbidity of lower limb arterial stenosis and more stenosis in low ABI group than in normal ABI group[100.0％ (38/38)vs 72.0％ (36/50),P ＜ 0.01].Conclusion baPWV combined with ABI examination has an important clinical value in early diagnosis of lower limb arterial lesions in elderly patients with hypertension.
Keywords：HypertensionPulse wave velocityAnkle-brachial indexLower limb artery
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1436-1440 )