Impact of smoking on young men with acute myocardial infarction

Wang Songtao; Tian Donghua; Li Nan

doi:10.3760/cma.j.issn.1673-4777.2014.10.003

Abstract：Objective To investigate the impact of smoking on coronary artery lesions in young men with acute myocardial infarction (AMI).Methods Totally 278 young men with AMI were retrospectively studied and compared with 208 non-coronary heart disease (CHD) young men.All patients were admitted from January 2009 to December 2011 and underwent coronary angiography; the clinic and coronary angiographic features were assessed.According to the results of coronary angiography,the patients were divided into two groups:the single vessel lesion group and multiple-vessel lesion group.208 young men without CHD confirmed by the coronary angiography were enrolled in the control group.The relation among smoking,AMI and severity of the coronary artery disease were observed.Results ①The ratio of smoking was significantly higher in young men with AMI group compared to that in non-CHD young men group [83.4％ (232/278) vs 65.4％ (136/208),P ＜0.05].In AMI group,the ratio of smoking in single lesions group was significantly lower than that in multiple vessel lesions groups [89.3 ％ (109/122) vs 78.8 ％ (123/156),P ＜ 0.05].②In the AMI group,the HDL-C levels were significantly lower than those in smoking group[(0.98 ± 0.25) mmol/L vs (1.09 ± 0.40) mmol/L,P ＜ 0.05].In both AMI and non-CHD groups,the ratio of obesity and overweight patients were higher than those of normal weight group.In AMI patients with metabolic syndrome,the ratio of smokers was higher [88.0％ (147/167) vs 11.9％(20/167),P ＜ 0.05].③Logistic regression analysis showed metabolic syndrome (OR =4.125,95 ％ CI:2.588-6.577,P ＜ 0.01),familial history of early coronary artery disease (OR =3.903,95％ CI:2.019-7.547,P ＜0.01),smoking history (OR =2.828,95％ CI:1.698-4.711,P ＜ 0.01),hemoglobin (OR =1.053,95％ CI:1.033-1.073,P ＜ 0.01) and serum uric acid (OR =1.004,95 ％ CI:1.001-1.006,P =0.003) were independent risk factors (P ＜ 0.05) for young men with AMI.Conclusion Smoking is an independent risk factor for young men with AMI.