Analysis of risk factors for ventilator-associated pneumonia in surgical intensive care unit
Ye Qing
Sun Jianping
Zhong Weijia
Li Qiang
Chen Yao
Gao Jie
Zhang Jinglan
Abstract：Objective To analyze the risk factors of ventilator-associated pneumonia ( VAP) in surgical intensive care unit .Methods Totally 117 non cardiac operative patients under mechanical ventilation over 48 hours were retrospectively studied .The patients were assigned into VAP group and non-VAP group.The clinical profiles of the two groups were collected and the independent risk factors of VAP were analyzed by multivariate lo -gistic regression.Results There was a significant difference between VAP group and non-VAP group in terms of acute physiology and chronic health evaluation scoring (APACHE) Ⅱscore, duration of intubation/tracheotomy, types of antibiotics used before diagnosed VAP , the existence of non-infectious disease , extrapulmonary infection sites, nasogastric tube for more than 2 days, enterable nutrition and hormones [20 ±8 vs 13 ±4, 17(12,29) d vs 3(2,5) d,≥3 kinds 69.2%(18/26) vs 9.9%(9/91),<3 kinds 30.8%(8/26)vs 90.1%(82/91), 30.8%(8/26)vs 10.0%(10/91), 76.9%(20/26)vs 29.7%(27/91), 96.2%(25/26)vs 54.9%(50/91), 61.5%(16/26) vs 13.2%(12/91), 73.1%(19/26)vs 14.3%(13/91)](P<0.05 or P<0.01).Patients in VAP group had statistically more complications (shock, kidney failure, heart failure, high incidence of multiple organ dysfunction syndrome), longer ICU stay and hospitalization time and worse prognosis [65.4%(17/26) vs 17.6%(16/91),50.0%(13/26)vs 7.7%(7/91), 26.9%(7/26)vs 8.8%(8/91),73.1%(19/26)vs 6.6%(6/91), 23 (18,38) d vs 5(4,8) d, 50 (34,63) d vs 28(20,38) d, 53.8%(14/26)vs 2.2%(2/91)](P<0.05 or P<0.01).Duration of intubation/tracheotomy, types of antibiotics, hormones for more than 2 days were inde-pendent risk factors of VAP [odds ratio (OR) =1.485, 95% confidence interval (CI) :1.157-1.907;OR=17.062, 95%CI:1.382-210.591; OR=37.838, 95% CI:2.447-585.172).Conclusion The study shows that Intubation/tracheotomy duration , type of antibiotics and hormones are the independent risk factors of VAP .
Keywords：Ventilator-associated pneumoniaRisk factorsSurgical intensive care unit
Publication Date：2014-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1301-1305 )