Analysis of pathogenic bacteria resistance and risk factors of death on ventilator-associated pneumonia pa-tients in emergency intensive care unit
Gong Li
Yu Nianming
Liu Haifeng
Abstract：Objective To analyze the clinical characteristics of ventilator-associated pneumonia ( VAP) in patients admitted to the emergency intensive care unit ( EICU) , pathogen distribution and drug resistance char-acteristics;to explore the risk factors for death in VAP patients .Methods The clinical data of 190 cases of VAP patients from June 2012 to May 2013 in the Second Hospital of Jiaxing city , were retrospectively analyzed .Clinical characteristics , distribution and drug resistance of pathogenic bacteria and death risk factors of death were ana -lyzed.Results Two hundred and forty-two strains of pathogens were isolated from 190 patients, with 184 strains of Gram-negative bacteria.74 Pseudomonas aeruginosa (40.2%) and 70 Escherichia coli (38.0%) were most com-mon pathogenic bacteria in Gram-negative bacilli.Antibiotic sensitive rate of Pseudomonas aeruginosa was 77.0%(57/74) and 73.0%(54/70) to amikacin and imipenem/cilastatin sodium.Antibiotic sensitivity rate of Esche-richia coli was 71.4%to ceftazidime and imipenem/cilastatin sodium.Age≥60 years [odds ratio (OR)=6.675, 95%confidence interval (CI):2.620-9.731], the cumulative organ ≥3[OR=3.225, 95%CI:1.337-7.806] and lack of nutrition therapy [OR=1.912, 95% CI: 1.043-8.522] were death risk factors for VAP patients . Conclusions Gram-negative bacteria are the main pathogenic bacteria of VAP patients in EICU .Comprehensive treatment should be applied to treat complicated multiple organ dysfunction and malnutrition to reduce VAP mortality.
Keywords：Ventilator-associated pneumoniaEmergency intensive care unitPathogensDrug re-sistanceDeath factor
Publication Date：2014-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1298-1300 )