Clinical observation of interferonα-2b combined with budesonide spray inhalation treating bronchiolitis

Chen Hongbing; Huang Guoling

doi:10.3760/cma.j.issn.1673-4777.2014.09.014

Abstract：Objective To evaluate efficacy and safety of interferon α-2b combined with budesonide spray inhalation for the treatment of bronchiolitis .Methods Totally 123 infants with bronchiolitis were divided into the observation group (interferonα-2b 3.0 ×106 IU combined with budesonide 1.0 mg spray inhalation, n=61) and the control group ( ribavirin 100 mg combined with budesonide spray inhalation , n=62 ); the treatment course of the two groups was 7 days.Total effective rate,clinical symptoms, blood gas changes time,white blood cells and peripheral blood T lymphocyte levels were used as observation indexes .Results The total efficiency of the obser-vation group was 98.4%(P<0.05)and was significantly better than that of the control group [98.4%(60/61) vs 82.2%(51/62)](P<0.05);the asthma fading time, hospital stays,Lowell scores lower than 3 points of time in observation group were significantly shorter than those in the control group [(2.5 ±1.0) d vs (3.7 ±1.1) d, (6.7 ±1.7)d vs (7.9 ±2.0)d,(2.9 ±0.9)d vs (3.1 ±1.1)d](P<0.05).The PaO2,SaO2,CD3 +and CD8 +for the observation group were higher than those of IFN group before treatment and those of control group after treat -ment[(73.5 ±1.0)mmHg vs (59.2 ±1.4),(65.2 ±1.2)mmHg;(93.3 ±2.8)%vs (82.9 ±4.1)%,(89.8 ± 2.1)%;(75 ±9)%vs (62 ±9)%,(66 ±10)%;(37 ±4)% vs (27 ±7)%,(26 ±7)%]; the difference was statistically significant (P<0.05).The white blood cell level of the two groups was not significantly different (P>0.05).Conclusion Interferonα-2b combined with budesonide spray inhalation for the treatment of bronchi -olitis is safe and effective .