Correlation analysis of serum homocysteine or high sensitivity C reactive protein and coronary heart dis-ease
Wu Zhihong
Ding Qiulei
Lian Xiaofang
Sun Yuran
Wang Xiangling
Ren Yanchun
Du Wei
Wang Yunying
Xu Lei
An Shaobo
Abstract：Objective To investigate the correlation of serum homocysteine ( Hcy) or high sensitivity C reactive protein ( hs-CRP) and coronary heart disease .Methods Serum Hcy and hs-CRP levels in 111 cases of coronary heart disease and 77 cases of healthy volunteers were measured and analyzed .Determination of serum Hcy was done by enzymatic cycling assay and determination of serum hs-CRP was done by immunoturbidimetric assay . 111 patients with coronary heart disease were divided into stable angina pectoris ( SAP group ) , unstable angina pectoris ( UAP group) and acute myocardial infarction ( AMI group) according to the conditions;the differences of Hcy and hs-CRP levels of each group were analyzed .Results Serum hcy level and serum hs-CRP levels in CHD group were significantly higher than those in the healthy control group [ ( 21 ±9 )μmol/L vs ( 9 ±6 )μmol/L, (15.1 ±1.4)mg/L vs (1.0 ±0.9)mg/L] (P<0.05).Serum Hcy levels and serum hs-CRP levels in AMI group were significantly higher than those in SAP group and UAP group [ ( 24 ±8 )μmol/L vs ( 16 ±5 )μmol/L, (19 ±6)μmol/L,(23.7 ±5.9)mg/L vs (4.0 ±3.0)mg/L,(15.4 ±3.2)mg/L](P<0.05).Serum Hcy levels and serum hs-CRP levels in UAP group were significantly higher than those in SAP group [ ( 19 ±6 )μmol/L vs (16 ±5)μmol/L,(15.4 ±3.2)mg/L vs (4.0 ±3.0)mg/L](P<0.05).Conclusions Serum Hcy and hs-CRP levels are consistent with coronary heart disease .The condition of coronary heart disease can be judged by serum Hcy and hs-CRP levels, and it is good for guiding the treatment .
Keywords：Coronary heart diseaseHomocysteineHigh sensitivity C reactive protein
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1271-1273 )