Intervention effect of simvastatin on atherosclerosis in patients with coronary atherosclerosis
Tian Guoxiang
Wu Yuntao
Zhang Wei
Wei Wanlin
Abstract：Objective To observe the intervention effect of simvastatin on development of atherosclerosis in patients with coronary atherosclerosis .Methods The patients (92 cases) with normal blood fat level but thick-ened carotid intima-media thickness ( CA-IMT ) were chosen .The patients were randomly divided into control group (46 cases) and observation group (46 cases).Control group was treated with routine therapy and health ed-ucation;observation group was treated with simvastatin ( 20 mg once every night ) plus the routine therapy and health education .Both groups were treated and followed up for one year .The levels of total cholesterol , triglycer-ides, high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and fasting plas-ma glucose and changes of CA-IMT and cardio-ankle vascular index ( CAVI) were detected and compared between the two groups before and after treatment .Results Lower limb muscle pain occurred in one patient in observation group;the level of creatine kinase increased 2 times after taking simvastatin for 3 weeks;the patient was withdrawn from the study.The levels of total cholesterol[(6.8 ±0.6)mmol/L vs (6.6 ±0.6)mmol/L], LDL-C[(3.6 ± 0.4)mmol/L vs (3.6 ±0.5)mmol/L],HDL-C[(1.0 ±0.4)mmol/L vs (0.9 ±0.5)mmol/L] and triglycerides [(2.6 ±0.5) mmol/L vs (2.6 ±0.5) mmol/L], changes of CA-IMT[(1.15 ±0.17) mm vs (1.14 ± 0.17) mm]and cardio-ankle vascular index (CAVI) (8.62 ±0.83 vs 8.57 ±0.72) had no statistical differences between observation group and control group before treatment (P>0.05).After one year of intervention, the lev-els of total cholesterol (5.5 ±0.5)mmol/L vs (6.6 ±0.6) mmol/L and LDL-C [(3.2 ±0.5)mmol/L vs (3.6 ± 0.5)mmol/L], CA-IMT[(1.12 ±0.17)mm vs (1.14 ±0.17)mm] and CAVI[(8.7 ±0.8) vs (8.6 ±0.7)]had no significant changes in control group (P>0.05); the levels of total cholesterol[(2.8 ±0.3)mmol/L vs (3.6 ±0.4)mmol/L], LDL-C[(2.8 ±0.3)mmol/L vs (3.6 ±0.4)mmol/L]and CA-IMT[(0.91 ±0.11)mm vs (1.15 ±0.17)mm]and CAVI[(8.1 ±0.7) vs (8.6 ±0.8)]decreased significantly in observation group (P<0.05);these indexes decreased significantly compared with control group (P<0.05).Conclusion Simvastatin can delay and reverse the development of coronary atherosclerosis ameliorating blood fat levels .
Keywords：Coronary atherosclerosisSimvastatinCarotid intima-media thicknessCardio-ankle vascular index
Publication Date：2014-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1267-1270,1271 )