Impact of intensive statin therapy on perioperative platelet parameters in older patients with non-ST seg-ment elevated acute coronary syndrome undergoing percutaneous coronary interventions procedure
Li Yueping
Zhao Yingxin
Liu Yuyang
Shi Dongmei
Zhou Yujie
Abstract：Objective To investigate the impact of intensive statin therapy on perioperative platelet pa -rameters in older patients with non-ST elevated acute coronary syndrome ( NSTE-ACS ) undergoing percutaneous coronary intervention (PCI).Methods A total of 138 patients, over 65 year′s age, with unstable angina pectoris or non ST segment elevation myocardial infarction were included .They were divided into conventional therapy group ( received 20 mg atorvastatin per day , n=70 ) and intensive treatment group ( received 80 mg load dose of atorvastatin then 40 mg per day, n=68) 12 hours before PCI.Blood platelet count (PLT), mean platelet volume (MPV), platelet distribution (PDW) and platelet-large cell ratio (P-LCR) were measured at baseline; platelet parameters were measured at day 1 and day 5 after PCI, including the platelet aggregation rate induced arachidonic acid and adenosine diphosphate .Results There were no significant differences on PLT , MPV, PDW, P-LCR af-ter admission and PCI at day 1 and day 5 between the two groups (P>0.05).Compared with base line, there were significant differences on PLT , MPV, PDW, P-LCR after admission and day 1 after PCI in conventional ther-apy group,[(206 ±62) ×109/L vs (210 ±60) ×109/L,(10.8 ±0.9)fL vs (10.6 ±0.9)fL, (12.8 ±1.9)%vs (12.5 ±1.9)%, (32 ±8)%vs (30 ±8)%] (P<0.05).The fifth day after PCI, there were no significant differences of platelet count, MPV, PDW, P-LCR in conventional treatment group and baseline (P>0.05).The first day after PCI , there were no significant differences of platelet count , MPV, PDW, P-LCR in intensive treat-ment group and baseline(P>0.05);there were significant differences in MPV and P-LCR in intensive treatment group and base line [(10.6 ±1.0)fL vs (10.8 ±1.0)fL, (30 ±9)%vs (31 ±8)%](P<0.05).The first and fifth day after PCI , there were no significant differences in platelet aggregation rate of AA and ADP in two groups ( P>0.05 ); there were no significant differences in platelet aggregation rate of AA and ADP abduction in all groups (P>0.05).Conclusions Atorvastatin may beneficially inhibit the increasing of MPV , PDW, P-LCR due to PCI.This effect of atorvastatin can play a role in decreasing platelet activation and reducing cardiovascular risk for NSTE-ACS patients .
Keywords：Acute coronary syndromeStatinsPlatelet parameterPercutaneous coronary interven-tion
Publication Date：2014-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1258-1261,1262 )