The relationship between plasma lipoprotein-associated phospholipase A2 and coronary atherosclerosis in patients with coronary heart disease
Zhang Dongqin
Zeng Yujie
Dong Daoran
Zhu Dan
Li Nan
Abstract：Objective To discover the relationship between the plasma lipoprotein-associated phospho-lipase A2 (Lp-PLA2) level, the stability of coronary atherosclerotic plaque and degree of coronary atherosclerosis in patients with coronary heart disease (CHD).Methods Two hundred and fifty-four patients who received the coronary angiography ( CAG) in China-Japan Friendship Hospital were selected .According to the CAG results , they were divided into CHD group (n=206) and control group excluded of CHD (n=48).According to the clini -cal types, the CHD group was further divided into subgroups of stable angina pectoris ( SAP), unstable angina pectoris ( UAP) and acute myocardial infarction ( AMI) .According to the number of diseased coronary branches , it was divided into subgroups of lesion in single , double or triple vessels .According to Gensini′score, the group was divided into three subgroups of 0 to 19 scores, 20 to 39 scores and ≥40 scores.Plasma levels of Lp-PLA2 were detected by enzyme-linked immunosorbent assay ( ELISA) .Clinical information and biochemical data such as age, sex, body mass index (BMI), prior medical history including hypertension , diabetes mellitus and smoking status, levels of total cholesterol(TC), triglyceride, low density lipoprotein-cholesterol(LDL-C), high density lip-oprotein-cholesterol ( HDL-C ) and high-sensitivity C-reactive protein ( hs-CRP ) were obtained before CAG . Results ①The level of Lp-PLA2 was significantly higher in CHD group than that in the control group [(180 ± 37)μg/L vs (160 ±44)μg/L, P<0.01].②Compared with the control group , levels of Lp-PLA2 were higher in SAP group, UAP group and AMI group[(183 ±38),(178 ±34),(181 ±38)μg/L vs (160 ±44)μg/L, all P<0.05].There were no significant differences in the levels of Lp-PLA2 between SAP, UAP and AMI group (P>0.05).③In CHD group, the level of Lp-PLA2 increased with the increasing number of diseased coronary bran-ches and Gensini′score[numbers of the pathological subgroups: (177 ±41),(182 ±32),(183 ±35)μg/L and each sub group of gensini integral:( 175 ±38 ) , ( 179 ±38 ) , ( 182 ±36 )μg/L vs ( 160 ±44 )μg/L, all P<0.05].However, there was no significant difference between the subgroups respectively (P>0.05).④Plasma levels of Lp-PLA2 were not related with age , sex, BMI, TC, triglyceride, LDL-C, HDL-C, hs-CRP, prior medi-cal histories including hypertension , diabetes mellitus and smoking status .⑤Age, smoking status and plasma level of Lp-PLA2 were independent risk factors of CHD .The levels of LDL-C, hs-CRP and Lp-PLA2 were related to the Gensini′score independently .Conclusions Plasma level of Lp-PLA2 is significantly high in CHD patients , which is an independent risk factor of CHD .To some extent , it can reflect the degree of stenosis in coronary artery .But the relationship between Lp-PLA2 levels and the stability of coronary atherosclerotic plaque needs further research .
Keywords：Coronary heart diseaseLipoprotein -associated phospholipase A 2Atherosclerosis
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1253-1257 )