Risk factors of coronary heart disease in young patienst
Yang Weixian
Yang Zheng
Wu Yongjian
Qiao Shubin
Yang Yuejin
Chen Jilin
Abstract：Objective To discuss the risk factors of coronary heart disease ( CHD ) in young patients . Methods The study population included 292 young patients who underwent coronary angiography from July 2006 to December 2006 at Fuwai hospital .According to the coronary angiography , CHD was diagnosed as ≥50%diam-eter stenosis in coronary lumen .There were 217 patients in CHD group and 75 cases with normal coronary lumen in non-CHD group.Clinical data and metabolic characteristics were collected and analyzed .Results More than half of the study subjects had body mass index (BMI) of >24 kg/m2 (230/292,78.8%); current smokers were (209/292,71.6%) and had rich fatty diet (162/292,55.5%).More patients were heavy smokers (smoking his-tory more than 10 years and more than 20 cigarettes per day) in CHD group [20.7%(45/217)vs 9.2%(7/75), P=0.015].The metabolic data analysis showed that total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), lipoprotein(LP)a, uric acid (UA) in plasma were significantly increased in CHD group and higher than those in non-CHD group (P<0.05 or P<0.01)[TC:(4.6 ±1.5)mmol/L vs (4.1 ±1.0)mmol/L, LDL-C:(2.4 ±1.1)mmol/L vs (2.1 ±0.6) mmol/L,(LP)a: (135 ±110)mg/L vs (102 ±58)mg/L,UA:(360 ± 100)μmol/L vs (337 ±94)μmol/L].Compared with non-CHD group, the ESR and big endothelin-1 were signifi-cantly higher than those in CHD group [5(2,13)mm/1 h vs 2(3,6)mm/1 h;0.450(0.290, 2.510)pmol/L vs 0.320(0.208, 0.475)pmol/L] (P<0.05 or P<0.01).hs-CRP had not significant difference between two groups[1.750(0.738, 3.755)mg/L vs 1.280(0.550, 2.71)mg/L](P>0.05).Multinomial logistic regression showed that significant risk factors (all P<0.01) included heavy smoking [odds ratio (OR)=1.89, 95%confi-dence interval (CI):1.74-2.05], hypertension (OR=1.56, 95% CI:1.48-1.65),alcohol (OR=1.37, 95%CI:1.30-1.46), diabetes (OR=1.37, 95%CI:1.25-1.50), rich fatty diet (OR=1.35, 95%CI:1.28-1.43) and BMI>24 kg/m2(OR=1.09, 95%CI:1.03-1.17).Conclusions Young people (age≤40) have a high pro-portion of BMI >24 kg/m2 , current smokers and rich fatty diet .The metabolic characteristics , including TC, LDL-C, LP(a), UA are unusual.ESR, hs-CRP and big endothelin-1 in plasma significantly increase in CHD group.Heavy smoker, hypertension, alcohol, diabetes, rich fatty diet and BMI>24 kg/m2 are significant risk fac-tors of CHD in these patients .
Keywords：Coronary heart diseaseYoung peopleRisk factors
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1249-1253 )