The association between ApoE gene polymorphisms and Alzheimer's disease in Chinese population:a Meta-analysis
Cui Hongli
Li Xiaofeng
Yan Yinan
Chen Weirong
Li Xinyi
Abstract：Objective To evaluate the relation between gene polymorphisms of ApoE and Alzheimer's disease in Chinese population.Methods The literatures were fully searched through computed databases,such PUBMED,CNKI,CBM,VIP and Wanfang.The relevant data were extracted according to the inclusion and exclusion criteria.RevMan 5.0 was applied to do heterogeneity test,data consolidation and sensitivity analysis.The publication bias was evaluated by Stata 12.0.Results The 11 eligible articles (13 studies) were included,a total of 2 577 cases,including 1 209 cases in the Alzheimer's disease group,1 368 cases in the control group.The meta-analysis showed that individuals with ApoE 4 allele and ε3/4,ε4/4 genotype were significantly associated with the risk of Alzheimer's disease[ε4 vs ε3:odds ratio(OR) =2.88,95％ confidence interval(CI) (2.41,3.44) ; ε3/4 vs ε3/3:OR =2.62,95％ CI(2.11,3.25) ; ε4/4 vs ε3/3:OR =7.98,95 ％ CI(4.21,15.13)].Individuals with ApoE ε2 allele and ε2/3 genotype were significantly associated with the risk of Alzheimer's disease[ε2 vs ε3:OR =0.77,95％CI(0.62,0.96); ε2/3 vs ε3/3:0R=0.76,95％CI(0.58,0.98)].Conclusion ApoE gene polymorphisms are closely associated with the occurrence of Alzheimer's disease in Chinese population.
Keywords：Apolipoprotein EPolymorphismAlzheimer's diseaseMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1141-1146 )