Observation of the clinical effects of amlodipine combine with losartan potassium/hydrochlorothiazide in the treatment of geriatric resistant hypertension
Abstract：Objective To observe the clinical effects of amlodipine combined with losartan potassium/hydrochlorothiazide in the treatment of geriatric resistant hypertension.Methods A total of 86 patients with geriatric resistant hypertension were included and the pre-/post-treatment blood pressure were compared.Patients were given amlodipine 5 mg/d or 10 mg/d,combined with losartan potassium/hydrochlorothiazide 62.5 mg/d po in the morning; blood pressure,heart rate,clinical symptoms and adverse reaction were recorded.The course of treatment was 8 weeks.Amlodipine can be adjusted to 10 mg/d and other medicine can be added depending on patients blood pressure during the fourth week.We tested the comprehensive metabolic panel,blood routine and urine routine before and after treatment.24 hours ambulatory blood pressure monitoring was performed before the treatment,4 weeks and 8 weeks after the treatment.Results Eight weeks after treatment,totally 86 cases of elderly patients with refractory hypertension had significantly decreased blood pressure [systolic blood pressure (135 ± 7) mmHg vs (168 ± 11) mmHg,diastolic blood pressure (79 ± 8) mmHg vs (91 ± 10) mmHg] (P ＜ 0.05).No significant differences in heart rate variation (P ＞ 0.05) were observed.Difference of blood biochemical indexes before and after treatment had no statistical significance (P ＞ 0.05).Conclusion Amlodipine combine with losartan potassium/hydrochlorothiazide is effective for the treatment of geriatric resistant hypertension.
Keywords：Resistant hypertensionAmlodipineLosartan potassium/hydrochlorothiazideSenium
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1108-1110 )