The risk factors of the death in elderly ischemic stroke and the value of D-dimer and high sensitivity C-reactive protein on the prognosis of patients
Jiang Jiwen
Liu Shuiping
Bi Qi
Abstract：Objective To discuss the death related factors of elderly patients with ischemic stroke and to evaluate the value of D-dimer and high sensitivity C-reactive protein(hs-CRP) on the prognosis in elderly patients with ischemic stroke.Methods Totally 886 consecutive ischemic stroke cases were retrospectively collected.The relevant factors of death,including admission blood pressure (systolic pressure and diastolic pressure),blood glucose,temperature,D-dimer,C-reactive protein,NIHSS total scores,Glasgow scores,the infarction site and degree of artery stenosis were analyzed.Death within 30 days was the endpoint.The risk factors were analyzed by univariate and multivariate Logistic regression.Results Totally 43 cases (4.8％) died in hospital.The differences of age,D-dimer,hs-CRP,urea nitrogen,albumin,fibrinogen,the proportion of complication,admission NIHSS total scores and admission Glasgow scores between the two groups had significance [(75 ± 10) years old vs (70 ±10)years old,(8.8 ±2.0)mg/L vs (5.2 ± 1.0) mg/L,(1.73 ±0.92) mg/L vs (1.04 ±0.28)mg/L,(9.6 ±5.1)mmol/Lvs (6.2±2.2)mmol/L,(37±5)g/L vs (42±5)g/L,(4.6±1.7)g/L vs (4.1 ±1.2)g/L,79.1％ (34/43) vs 8.2％ (69/843),(16.3 ± 7.2) scores vs (7.1 ± 5.3) scores,(8.0 ± 3.3) scores vs (12.0 ±2.6) scores] (P ＜0.05 or P ＜ 0.01).Multivariate Logistic regression analysis showed that Glasgow score was a protective factor[odds ratio(OR) =0.642,95％ confidence interval (CI):-0.730-0.893] of the patients.hsCRP (OR =1.243,95％ CI:1.012-1.523),D-dimer (OR =2.231,95％ CI:1.426-4.117),admission NIHSS total scores (OR =1.226,95 ％ CI:1.112-1.412) and complications [OR =65.03,95 ％ CI:11.433-363.626]were independent risk factors among elderly patients with acute ischemic stroke.Conclusion Old age,complications,D-dimer,hs-CPR,admission NIHSS total scores and admission Glasgow scores are independent risk factors of poor outcomes of ischemic stroke.
Keywords：Ischemic strokeDeathRisk factorsD-dimerHigh sensitivity C-reactive protein
Publication Date：2014-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 995-999 )