Influence of glomerular filtration rate on hemorrhagic transformation in patients with acute ischemic stroke
Liu Penju
Zhang Xiaoting
Liu Shuiping
Abstract：Objective To investigate the relation between the glomerular filtration rate (GFR) and the risk of hemorrhagic transformation in acute ischemic stroke patients.Methods We consecutively enrolled 581 acute ischemic stroke patients.The baseline demographic clinical and laboratory information were collected.All the patients were assigned to hemorrhagic transformation [(HT) group,n =54] or non-HT (n =527) by the imaging findings.The estimate GFR was calculated with the use of the Chroinc Kidney Disease-Epidemiology Collaboration (CKD-EPI) equaution.The impact of the GFR on the hemorrhagic transformation was investigated.Results The univariate analysis showed the HTs were more frequent in patients with atrial fibrillation,diabetes,large-size infarction and decreased GFR(P ＜ 0.05).The multiple logistic regression analysis showed there was a significant association between the[GFR ＜ 30 ml/(min · 1.73 m2)] group and HTs in acute ischemic stroke(OR =3.17,95％ CI:1.37 to 8.28).Compared with normal renal function patients,the incidence of HTs was higher in the [GFR＜30ml/(min· 1.73 m2)]group(OR=16.04,95％CI:11.21 to 253.68).Conclusion Low levels of GFR are associated with a high risk of HT after acute ischemic stroke and the decrease of GFR may be a prognosis of the HT after acute ischemic stroke.
Keywords：Glomerular filtration rateHemorrhagic transformationRisk factors
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 982-986 )