Clinical features and antibiotic susceptibility of staphylococcus aureus pneumonias

Gong Yan; Xu Wenxia

doi:10.3760/cma.j.issn.1673-4777.2014.07.013

Abstract：Objective To analyze and summarize the clinical features and distribution of antibiotic susceptibility of staphylococcus aureus pneumonia.Methods The clinical data of 50 cases staphylococcus aureus pneumonia was analyzed retrospectively.All bacteria isolated were identified by the routine method according to national guide to clinical laboratory procedures and were cultured with the blood agar,chocolate agar and MacConkeyAgar.Suspected colonies identification was performed by Gram staining and biochemical reaction.Staphylococcus aureus were Gram-positive coccus.ID identification strip was employed by MicroScan walk Away-96 and drug susceptibility test was performed when bacteria identified as staphylococcus aureus.Results All 23 patients who had fever accounted for 46.0％ in the 50 cases.The clinical symptoms were mainly cough(43/50,86.0％),expectoration(41/50,82.0％),dyspnea (16/50,32.0％) and pulmonary moist rale (31/50,62.0％).Peripheral white blood cells increased in 19 cases and decreased in 4 cases.Chest X-ray showed mainly flaky and patchy shadows.There were 6 cases of segmental exudative lesions and the bronchial patchy effusion in 44 cases.13 cases of 50 patients were from geriatrics department; 9 cases were from neurology department; 9 cases were respiratory medicine department; 4 cases were from cardiovascular medicine department; 4 cases were from endocrinology department; 4 cases were from surgical department; 3 cases were from cardiology department; 2 cases were from emergency observation room; 1 case was from gastroenterology department and 1 case was from hematology department.Staphylococcus aureus isolated were sensible to vancomycin,linezolid,rifampicin and chloroamphenicol,which accounted for 100％,100％,85.7％ and 78.6％ respectively,but they had resistance to any other antibiotics.Among the total 50 patients,27 cases(54.0％) were cured and 16 cases(32.0％) were effective; the total effective rate was 86.0％.7 cases(14.0％) died.The causes of death were acute exacerbation of chronic pulmonary disease combined with type Ⅱ respiratory failure(1/7),septicemia(1/7),severe pneumonia(1/7),interstitial lung disease combined with infection (1/7),non-hodgkin lymphoma (1/7),lung cancer metastasis (1/7)and cerebral infarction(1/7).Conclusions Staphylococcus aureus pneumonia is common in the elderly.Patients with underlying diseases and the immunocompromised population.Early selection of susceptive antibiotics and performing drug susceptibility test can improve the prognosis.