Effects of homocysteine and high sensitivity C-reactive protein on chronic heart failure
Qian Weili
Yang Xinchun
Zhang Juan
Liu Mingli
Abstract：Objective To investigate the effects of homocysteine(Hcy) and high sensitivity C-reactive protein (hs-CRP) on chronic heart failure [including cardiac function classification,left ventricular diastolic diameter (LVDD),left ventricular ejection fraction(LVEF)].Methods The plasma levels of HCY and CRP were tested in 59 patients with heart failure (heart failure group) and 29 healthy volunteers (control group).The LVDD and LVEF were detected by colour Doppler ultrasound.Results HCY of heart function Ⅱ group,NYHA Ⅲ group,NYHA Ⅳ group and the control group were (14.6 ± 1.4) μmol/L,(19.3 ±4.5) μmol/L,(29.6 ± 6.6) μmol/L (9.4 ± 1.2) μmol/L,respectively; hs-CRP were (4.2 ± 2.2) mg/L,(12.6 ± 3.7) mg/L,(14.7 ± 2.6) mg/L,(3.7 ± 1.4) mg/L,respectively.The levels of HCY and hs-CRP increased with cardiac function.The plasma level of Hcy was positively correlated with the severity of NYHA class (r =0.769,P ＜ 0.05) and LVDD(r =0.706,P ＜ 0.05),but it was negatively correlated with LVEF (r =-0.856,P ＜ 0.05).The plasma level of hs-CRP was positively correlated with the severity of NYHA class (r =0.377,P =0.02),but it was not correlated with LVDD (r=0.347,P=0.072)and LVEF(r =0.204,P=0.058).Conclusions The levels of Hcy and hs-CRP are increased with severity of NYHA class.The level of Hcy has correlations with the heart function.
Keywords：Chronic heart failureHomocysteinehigh sensitivity C-reactive protein
Publication Date：2014-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 963-967 )