Different influences of C-reactive protein and lipid profile on coronary lesions after a percutaneous coronary intervention

Liu Dongling; Fan Zeyuan; Jian Xinwen; Li Li; Tian Junyuan; Wang Na; Liu Tao

doi:10.3760/cma.j.issn.1673-4777.2014.07.003

Abstract：Objective To investigate the impacts of inflammation and lipid profile on both in-stent restenosis(ISR) and lesion progression in patients receiving PCI and scheduled follow-up.Methods A retrospective analysis of 515 patients was performed in patients who underwent percutaneous coronary intervention(PCI) and received coronary angiography again at an average of 9 months.The data of lipid profile and C-reactive protein (CRP) at both pre-PCI and follow-up were analyzed for all patients; 317 patients with neither ISR nor lesion progression were as a control group.Results CRP levels of pre-PCI in the ISR group were higher than those in the control group (P ＜ 0.05).The multivariate analysis indicated that the CRP levels at both pre-PCI and follow-up were significantly correlated with ISR [OR =1.010,95％ CI:1.007-1.1920,P ＜0.05 for pre-PCI,OR =1.158,95％ CI:1.057-1.269),P ＜ 0.05 for follow-up,P ＜ 0.05,respectively].When the cut-off of CRP was 2 mg/L,logistic regression analysis suggested an increased risk of ISR in patients with CRP greater than 2 mg/L (OR =1.830,95 ％ CI:1.034-3.462,P ＜ 0.05) at pre-PCI CRP.The levels of total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) during follow-up in the progression group were higher than those in the control group (P ＜ 0.05,respectively).Logistic regression showed that the risk for lesion progression was associated with the concentrations of TC,LDL-C and non-HDL-C (P ＜0.05).Conclusions The levels of pre-PCI CRP are strongly associated with ISR,whereas serum levels of TC,LDL-C and non-HDL-C are significantly correlated with coronary lesion progression.