Meta-analysis of the efficacy of the hydrotalcite treating bile reflux gastritis
Luo Jinjian
Abstract：Objective To evaluate the efficacy of the hydrotalcite treating bile reflux gastritis.Methods Data from medline,Health knowledge of evidence based medicine warehouse Western biomedical literature database,Wanfang database,CBM disk,VIP information database and china hospital digital library were searched and the references of related studies were checked.The textbooks and meeting reports related to hydrotalcite were manually searched.The quality of included studies was evaluated.Data was extracted into a specially designed extraction form.Control group adopted symptomatic and supportive treatment; study group had symptomatic and supportive treatment combined with hydrotalcite.The Cochrane collaboration's RevMan4.2 software was used for data analysis.Results Eleven randomly controlled clinical studies involving 770 patients were included.The pooled results showed that there were significant differences of the clinical symptom efficacy and the bile reflux disappear rate of the bile reflux gastritis between the hydrotalcite treatment group and the controlled group(combined odds ratio was 6.18 (95 ％ confidence interval:3.89-9.81) and 4.81 (95 ％ confidence interval:3.25-7.12) respectively.Z value was 7.72 and 7.85 respectively; P value was less than 0.01 and 0.01 respectively) ; analysis of publication bias showed that the inverted funnel plot had two dissymmetrical sides.Conclusions Clinical symptom efficacy and the bile reflux disappear rate of the hydrotalcite treatment are not superior to those of the controlled group in treating bile reflux gastritis.Randomized,prospective,double-blind,multi-center and large-scale samples of clinical trials are needed.
Keywords：Bile reflux gastritisHydrotalciteMeta-analysisBile reflux disappear rate
Publication Date：2014-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 822-825 )