Clinical investigation of high sensitivity C-reactive protein and hemoglobin A1c in acute coronary syndrome

doi:10.3760/cma.j.issn.1673-4777.2014.06.010

Abstract：Objective To explore the correlation between high sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin A1 c(HbA1 c) in adult with acute coronary syndrome(ACS).Methods Coronary artery angiography(CAG) was done for all the subjects by Judkins'methods; 80 ACS patients were performed.The control group consisted of 32 subjects without CHD,including 6 diabetes.According to the severity of coronary artery stenosis,80 ACS patients were divided into three groups:single-artery lesions,doubie-artery lesions and multi-artery lesions; according to the type of ACS,80 patients were dinvided into unstable angina pectoris(UA) and acute myocardial infraction (AMI).The serum content of hs-CRP was measured by enhanced immunoturbidimetric assary (ITM).HbA1c was measured by liquid chromatography(LC) method.Results hs-CRP levels in all observation groups were significantly higher than those in the control group [(7.85 ± 5.89),(4.49 ± 2.68),(8.79 ± 5.09),(9.37 ± 5.49),(10.93 ± 4.56),(4.89 ± 2.09) mg/L vs (1.56 ± 1.03) rmg/L,all P ＜ 0.01].HbA1 c levels had no statistical significant difference compared with the control group [(6.48 ± 1.32) ％,(6.33 ± 1.60) ％,(6.54±1.68)％,(6.79±1.32)％,(6.49±1.46)％,(6.52±1.32)％ vs (6.32±1.20)％,allP＞0.05].hs-CRP were positively correlated with the lesion counts and the lesion types (r =0.63,r =0.74,P ＜ 0.01).HbA1c had no correlation with lesion counts and the lesion types (r =0.09,r =0.09,P ＞ 0.05).Conclusions In the coronary syndrome patients,the concentration of the hs-CRP increased and it is positively correlated with the unstable states of atherosclerotic plaque.But HbA1c has no correlation with unstable coronary atherosclerotic plaque.hs-CRP levels are not correlated with HbA1c's.HbA1c reflect chronic pathological process of atherosclerotic,but hs-CRP can be used as a factor detecting the unstable states of atherosclerotic plaque.