Efficacy and safety of triple antiplatelet therapy in patients with diabetes mellitus combined with coronary heart disease after percutaneous coronary intervention
Li Shihong
Yan Dong
Chen Xuanzu
Lin Yun
Zhang Jingmei
Li Zhizhong
Huang Ji
Abstract：Objective To observe clinical efficacy and safety of aspirin,clopidogrel and cilostazol antiplatelet therapy in diabetic patients after percutaneous coronary intervention (PCI) in the prevention of stent restenosis.Methods Totally 166 patients with coronary heart disease (CHD) were divided into control group (80 cases) and observation group (86 cases).Control group was given 100 mg/d of aspirin and clopidogrel 75 mg/d.Observation group was given thiazole 100 mg/d on the basis of the control group.The difference of the baseline data,the results of coronary angiography and PCI,the primary end point and the difference of incidence of secondary end point index were recorded.Results Minimal lumen diameter of observation group was obviously higher than that of control group[(2.76 ± 0.53) mm vs (1.35 ± 0.32) mm,P ＜ 0.05].Late lumen loss,restenosis rate in observation group were significantly lower than those in the control group [(1.28 ± 0.33) mm vs (0.71 ±0.23)mm,P ＜0.05].At one month and 12 months follow-ups,the incidence rate of the primary end point index in observation group was significantly lower than that in control group; the difference was statistically significant [1 month:2.3％ (2/86) vs 8.8％ (7/80),2.3％ (2/86) vs 11.2％ (9/80),P＜0.05; 1 year:5.8％ (0/86) vs 11.2％ (1/80),P ＜ 0.05].The incidence of secondary end points had no statistically significant difference [1 month:1.16％ (2/86) vs 1.25％ (1/80) ; 1 year:2.3％ (2/86) vs 2.5％ (2/80),P ＞0.05].Conclusion PCI postoperative prevention of in-stent restenosis in patients with clopidogrel,aspirin and cilostazol can further reduce major adverse cardiovascular event rates and does not increase the risk of bleeding.
Keywords：Coronary heart diseasePercutaneous coronary interventionAnti platelet therapyCilostazol
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 774-778 )