Correlation between adiponectin and insulin in non-alcoholic fatty liver disease
Wei Wei
Zhong Huang
Huang Zhong
Abstract：Objective To investigate the expression level of adiponectin and insulin in non-alcoholic fatty liver disease(NAFLD) and explore the correlation between adiponectin and insulin.Methods Totally 50 NAFLD cases were as observation group and contemporary 40 normal were as control group; the adiponectin of fasting and postprandial 2 hours of 50 NAFLD cases and contemporary 40 normal control was determined by enzyme linked immunosorbent assay(ELISA) ; insulin of fasting and postprandial 2 hour was determined by chemi-luminescence.The correlation between the two factors of fasting and postprandial 2 hour was analyzed.Results There was a statistical significant expression of fasting serum adiponectin in observation group [(912 ± 29) μg/L vs (1 033 ± 53)μg/L,P ＜ 0.05].There was a statistical difference of insulin of fasting between observation group and control group [(13.8 ± 1.0) mU/ L vs (7.3 ± 1.0) mU/L,P ＜0.01].There was a statistical significance of expression of postprandial 2 hour serum adiponectin in observation group [(854 ± 38) μg/L vs (1 010 ± 48) μg/L,P ＜ 0.05].There was a statistical difference of insulin of postprandial 2 hour between observation group and control group[(112 ± 23)μg/L vs (28 ± 3)μg/L,P ＜ 0.01].The expression level of adiponectin and insulin in either fasting or postprandial 2 hour had a negative correlation(fasting r =-0.328,P =0.02 ; postprandial 2 hour r =-0.391,P =0.005).Conclusion With the NAFLD progressing,there is a negative correlation between insulin and adiponectin expression level.
Keywords：Non-alcoholic fatty liver diseaseInsulinAdiponectinCorrelation
Publication Date：2014-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 674-676 )