Risk factors of patients with type 2 diabetes complicated with nephropathy
Cao Jin
Zhou Yan
Wu Dafang
Abstract：Objective To explore the related risk factors of type 2 diabetic patients with diabetic nephropathy.Methods A retrospective research on 258 cases of type 2 diabetes mellitus was done.All of these patients were randomly divided into simple diabetes mellitus group (SDM),early diabetic nephropathy group (EDN) and clinical diabetic nephropathy group(CDN) according to the urinary protein excretion rate(UAER).The relevance of the related factors of the two groups was analyzed.Saccharifying enzyme hydrolysis of glucose was adopted to detect fasting plasma glucose ; radioimmunoassay method was adopted to detect insulin ; the liquid ion exchange method was used to detect glycosylated hemoglobin (HbA1 c),enzymatic method was used to detect serum total cholesterol,high-density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) ; triglyceride and urinary albumin quantitative were determined by radioimmunity method.Insulin and fasting blood glucose were used to determine insulin resistance index (HOMA-IR).Results The course of disease,body mass index,HDL-C,LDL-C,VLDL-C,fasting plasma glucose,insulin and HbA1 c were significantly different among the three groups [(5.5 ± 1.3),(7.0 ± 1.6),(8.5 ± 2.1) years ; (23 ±4),(24 ±47),(26 ±4) kg/m2 ; (1.75 ±0.46),(1.48 ±0.82),(1.15 ±0.59) mmol/L; (2.46 ± 0.76),(2.86 ±0.62),(3.12 ± 0.58) mmol/L; (0.57 ±0.48),(0.68 ±0.32),(0.82 ±0.35)mmol/L ; (9 ±3),(10 ± 4),(10 ±3)mmol/L;(10 ±4),(9 ±4),(8 ± 3) mU/L; (4.26 ± 2.01),(6.43 ± 2.46),(8.07 ± 2.51)％] (P =0.032,0.021,0.041,0.037,0.045,0.038,0.041,0.015).Regarding age,systolic pressure,diastolic blood pressure,uric acid,total cholesterol and three acyl glycerin,there were no statistically significant differences observed (P value were 0.089,0.089,0.091,0.081,0.083,0.081,0.083,respectively).There were four factors including the course of disease,body mass indes,LDL-C,VLDL-C and HbAlc(P =0.032,0.027,0.002,0.035,0.021)affecting the outcomes.HDL-C,fasting blood glucose and insulin and diabetic nephropathy had no correlation with diabetic nephropathy (P value were 0.062,0.058,0.054,respectively).Conclusion Course of the disease,obesity,hyperglycemia,hyperinsulinemia and hyperlipidemia are the risk factors of type 2 diabetic patients with diabetic nephropathy.
Keywords：Diabetes mellitus,type 2Diabetic nephropathyRisk factorUrinary albumin
Publication Date：2014-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 667-671 )