Study on effect of combined treatment of traditional Chinese medicine and western medicine on myocardial ischemia induced by mental stress
Li Qiaoyuan
Liu Mengchao
Liu Meiyan
Guo Chengjun
Abstract：Objective To investigate the effect of combination of traditional Chinese medicine and western medicine on myocardial ischemia induced by mental stress.Methods Totally 12 cases with coronary heart disease were put into combined treatment of traditional Chinese medicine and western medicine(group Ⅰ).According to the sex,age,blood pressure(BP) and heart rate(HR),other 12 cases with stable coronary heart disease were chosen as the conventional treatment group (group Ⅱ).Group Ⅰ was given aspirin 0.1 g once daily,metoprolol 25 mg two times per day and atorvastatin 10 mg qn.Group Ⅱ had also Zhenyuan capsule 0.25 g three times per day.We compared the blood pressure,heart rate before and after the standard stress testing.After 8 weeks,the two groups were compared regarding the changes of blood pressure,heart rate,PHQ-9 score and GAD-7 score.Results After standard stress test,ST-T elevated with (0.051 ± 0.0 1 8)mm (P ＜ 0.05).After eight weeks of combining traditional Chinese and western medicine treatment,diastolic blood pressure,PHQ-9 scores and GAD-7 score in Chinese and western medicine treatment group were reduced ; the differences were statistically significant [(76 ± 5) mmHg vs (92 ± 6) mmHg,(69 ± 4) times per min vs (83 ± 6) times per min,4.5 ± 1.2 vs 7.8 ± 3.4,2.3 ± 1.4 vs 5.8 ± 3.8,respectively] (all P ＜0.05).Diastolic blood pressure,PHQ-9 scores and GAD-7 score in conventional treatment group had no obvious changes compared with before treatment and there were no statistically significant differences [(76 ± 5) mmHg vs (90 ± 8) mmHg,(67 ± 6) times per min vs (84 ± 7) times per min,5.8 ± 2.8 vs 7.6 ± 3.9,5.2 ± 3.7 vs 5.9 ± 3.3] (all P ＞ 0.05).PHQ-9 score and GAD-7 score in traditional Chinese and western medicine group were reduced after treatment compared with the conventional treatment group; the difference was statistically significant (all P ＜ 0.05).Conclusion Combined treatment with traditional Chinese medicine and western medicine can improve the state of myocardial ischemia induced by mental stress.
Keywords：Myocardial ischemiaMental stressCombined treatment of traditional Chinese medicine and western medicine
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 624-627 )