Clinical analysis of captopril combined with nifedipine in the treatment of type 2 diabetes and hypertension
Xu Li
Chen Gang
Zhang Youzhang
Abstract：Objective To evaluate the clinical efficacy of captopril combined with nifedipine in treatment of type 2 diabetes and hypertension.Methods All 240 cases of hypertension complicated with type 2 diabetes were randomly divided into three groups.Metformin and sulfonylurea were used to control blood sugar in 3 groups.Captopril group received captopril 25 mg,3 times/d.nifedipine group received nifedipine 10 mg,2 times/d.Combined group received both drugs with the same dosage in captopril group and nifedipine group.2 months was a course and the clinical efficacy was compared.Results The number of effective cases of combined group was 51 cases; the total effective rate was 92.5 ％,which was significantly higher than that of captopril group and nifedipine group [76.2％ (25 cases),68.7％ (21 cases)].Systolic blood pressure,diastolic blood pressure,2 h postprandial blood glucose (2 h PBG),glycated hemoglobin (HbA1 c),serum creatinine (Scr) and blood urea nitrogen (BUN) in combined group were significantly different compared with other groups(F:5.73,4.56,4.10,3.05,42.35,7.93,P ＜0.05).Conclusion Captopril combined with nifedipine is effective and safe in the treatment of type 2 diabetes and hypertension.
Keywords：HypertensionCaptoprilNifedipineDiabetes
Publication Date：2014-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 506-508 )