The therapeutic efficacy of metformin combined with exercise therapy in the treatment of antipsychotic induced glucose and lipid metabolism disorder
Zhang Yusheng
Jia Jimin
Zhang Yuxiang
Abstract：Objective To investigate the therapeutic efficacy of mefformin combined with exercise therapy in the treatment of antipsychotic induced glucose and lipid metabolism disorder.Methods All 200 cases of mental hospital of schizophrenia patients were chosen and randomly divided into control group (100 cases,the continued use of antipsychotic drugs and by metformin treatment) and study group (100 cases,on the basis of the control group combined with exercise therapy).Body mass,waist circumference,fasting and 2 h postprandial blood glucose (FBG,2 h PG),lipid profile,serum resistin,insulin resistance index (IR),glycosylated hemoglobin (HbA1 c) and adiponectin in two groups of patients before and after treatment were compared.Results The control group before treatment,body mass,waist circumference,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,insulin resistance index,triacylglycerol,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol were (65 ± 8) kg,(84 ± 5) cm,(7.2 ± 1.5) mmol/L,(10.8 ± 2.2)mmol/L,(7.8 ±0.6)％,(6.3 ±2.6),(2.5 ±0.3)mmol/L,(6.2 ± 1)mmol/L,(0.7 ±0.2)mmol/L,(3.4± 0.4)mmol/L,after treatment were (63 ± 6) kg,(83 ± 4) cm,(6.5 ± 1.3) mmol/L,(7.8 ± 0.6)mmol/L,(6.5±0.4)％,(3.5 ±0.7),(2.2±0.3)mmol/L,(5.6±0.9)mmol/L,(1.0±0.3)mmol/L,(2.6 ±0.3)mmol/L; the study group before treatment,body mass,waist circumference,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,insulin resistance index,three triacylglycerols,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol were (65 ± 8) kg,(84 ± 5) cm,(7.3 ± 1.6)mmol/L,(10.6 ±2.3)mmol/L,(7.9 ±0.6)％,(6.4 ±2.5),(2.6 ±0.3) mmol/L,(6.3 ± 1.1) mmol/L(0.7 ± 0.2) mmol/L,(3.3 ± 0.4) mmol/L,after treatment were (58 ± 6) kg,(80 ± 4) cm,(5.7±l.2)mmol/L,(7.3±0.5)mmol/L,(6.1 ±0.4)％,(2.9±0.6),(1.8±0.3)mmol/L,(4.9± 0.8)mmol/L,(1.3 ±0.3)mmol/L,(2.3 ±0.3) mmol/L,The study group after 12 weeks of treatment,body mass,waist circumference,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,insulin resistance index,total cholesterol,triacylglycerol,low density lipoprotein cholesterol breakdown was lower than the control group,high density lipoprotein cholesterol was higher than the control group,the difference was statistically significant (P ＜ 0.05).Before treatment,there was no significant difference in the 2 groups of patients with serum resistin and adiponectin [control group was (45 ± 13),(30 ± 10) μg/L; study group was (45 ± 13),(30 ± 10) μg/L,P ＞0.05].After 12 weeks of treatment,blood resistance number,adiponectin fat cells factor in the study group was significantly lower than the control group after treatment [(35 ± 8) μg/L vs (43 ± 8) μg/L,(22 ± 9) μg/L vs (28 ± 9) μg/L,P ＜ 0.05].Conclusion Combined with exercise therapy,metformin can balance the fat cell factor and improve insulin function.
Keywords：Lipid metabolismAntipsychoticsMetforminExercise therapy
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 502-505 )