Effects of tracheal intubation with dexmedetomidine combined etomidate induced anesthesia on hemodynamic in hypertensive patients undergoing uvnlopalatopharyngoplasty
Zhao Rui
Li Haichun
Abstract：Objective To study effects of tracheal intubation with dexmedetomidine combined etomidate induced anesthesia on hemodynamic in hypertensive patients undergoing uvnlopalatopharyngoplasty (UPPP).Methods Forty hypertensive patients,grade Ⅱ to Ⅲ,apnea hypopnea index (AHI) from 25 to 45 undergoing UPPP were randomly divided into two groups:dexmedetomidine combined etomidate group(ED group,20 cases),dexmedetomidine given a loading dose of 0.6 μg/kg intravenous injection,15 min after the injection before induction of anesthesia; etomidate group(EN group)with normal saline injection.The two groups were fast nasal tracheal intubation after induction of anesthesia with 0.3 mg/kg etomidate.It were recorded that systolic blood pressure,diastolic blood pressure,heart rate in intubation and 1,3,5 min after intubation.Results Dexmedetomidine combined etomidate induced of anesthesia before surgery,intubation,1min after intubation,3 min after intubation,5 minafterintubation systolic pressure were (169 ± 13),(126 ± 10),(120 ± 10),(117 ± 13),(112 ± 16) mmHg; diastolic blood pressure as (103 ± 10),(95 ± 12),(95 ± 12),(89 ± 10),(83 ± 16) mmHg; heart rate was (89 ± 12),(89 ± 10),(84 ± 15),(85 ± 12),(83 ± 12) times/min; etomidate induction of anesthesia before surgery,intubation,1 min after intubation,3 min after intubation,5 min after intubation systolic pressure were (165 ± 11),(110 ± 12),(108 ± 9),(105 ± 13),(104 ± 16) mmHg; diastolic blood pressure (respectively.106±11),(79± 13),(75 ±6),(79±12),(76± 10) mmHg; heart rate was (86± 12),(65 ± 10),(76 ± 14),(75 ±11),(74 ±9)times/min.Systolic blood pressure,diastolic blood pressure,heart rate in group ED was significantly lower than group EN,in endotracheal intubation,intubation after 1 min,3 min,there were statistically significant between two groups(P ＜0.05).Conclusion Dexmedetomidine combined etomidate induced anesthesia in patients with hypertension uvnlopalatopharyngoplasty can reduce stress and maintain the stability of circulation during tracheal intubation.
Keywords：HypertensionDexmedetomidineEtomidateUvnlopalatopharyngoplasty
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 468-470 )