Influence of carbachol on myocardium in patients with intestinal barrier dysfunction induced by emergency trauma
Wang Yinhua
Wang Baohua
Tang Minggui
Chai Haixia
Pu Jianyi
Abstract：Objective To explore protection of carbachol for myocardium in patients with intestinal barrier dysfunction induced by emergency trauma.Methods Seventy patients after trauma with a definite diagnosis of multiple organ dysfunction syndrome in intensive care unit were included,were randomly divided into the carbachol group (n =37) and mosapride citrate group(n =33).Diamine oxidase activity,expressions of CD11b + and CD18 on polymor phonuclear meutrophilc(PMN) in peripheral blood and left ventricular ejection fraction(LVEF) were detected on the 1st and 7th day,as well as the peak contents of creatine kinase-MB (CK-MB).Clinical effects were observed.Results After treatment of 7 days,26 cases(70.3％) in carbachol group were effective in treatment,7 cases(18.9％)died,while 15 cases(45.5％) in mosapride citrate group were effective in treatment,13 cases(39.4％) died.Carbachol group showed a higher effective rate than the mosapride citrate group,thus the scores had statistical difference(x2 =4.43,P ＜ 0.05).On the 1 st day,diamine oxidase,CD11b + and CD18 in carbachol group was(4.8 ± 0.5) kU/L,(30.6 ± 3.6) ％,(75.8 ± 3.6) ％,on 7th day was (3.2 ± 0.5) kU/L,(14.9 ± 2.2)％,(53.7 ± 2.4)％.On the 1 st day diamine oxidase,CD11b + and CD18 in mosapride citrate group was(4.7 ±0.3)kU/L,(31.1 ±2.9)％,(74.6 ±2.7)％,on 7th day was(3.9 ±0.5) kU/L,(28.9 ± 1.6)％,(72.5 ± 4.1)％.After treatment of 7 days,diamine oxidase,CD11b + and CD18 in carbachol group was lower than the inclusion spot and mosapride citrate group,thus the scores had statistical difference(P ＜0.05).CK-MB had no statistical difference at the moment of entering between the two groups.But in carbachol group,the peak contents of CK-MB was lower than that of mosapride citrate group[(60 ± 19)U/L vs (79 ± 18)U/L],scores had statistical difference(P ＜ 0.05).Left ventricular ejection fraction had no statistical difference at the moment of entering the group between the two groups.But in carbachol group,the peak was higher than that of mosapride citrate group[(60-± 19) U/L vs (79 ± 18) U/L],thus the score had statistically difference (P ＜ 0.05).Conclusions To the patients of intestinal barrier dysfunction induced by emergency trauma,by lessening the ischemic/reperfusion injury,inhibiting the production of inflammatory cytokines in vivo and promoting peristalsis of intestinal tract.Carbachol can loosen the myocardium injury and protect remote organ-heart function.
Keywords：Myocardium injuryCarbacholEmergency traumaIntestinal barrier dysfunction
Publication Date：2014-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 464-467 )