Study on type 2 diabetes mellitus with colorectal cancer

Luo Xiuting; Xu Angao; Chen Liqiang; Lin Kexuan

doi:10.3760/cma.j.issn.1673-4777.2014.03.016

Abstract：Objective To discuss the correlation between type 2 diabetes mellitus and colorectal cancer; to analyze the features of colorectal cancer with type 2 diabetes. Methods Clinical data of 844 patients with colorectal cancer and 1275patients without tumor were collected; colorectal cancer patients were divided into colorectal cancer patients with type 2 diabetes mellitus group and colorectal cancer patients without type 2 diabetes mellitus. Sex, age distribution, histological type Dukes and lesion distribution in both groups were compared. Results There were 245 cases(29.0%) of colorectal cancer with type 2 diabetes and 103 cases (8.1%)of colorectal cancer without type 2 diabetes. Logistics binary regression model analysis results showed that type 2 diabetes was a risk factor for colorectal cancer (OR=3.572,P=0.000). Age ≥ 60 years in colorectal cancer patients with type 2 diabetes group were 153 cases ( 62.4% ),40 to 59 years were 82 cases ( 33.5% ) , <40 years were 10 cases ( 4.1% );Age ≥ 60 years in colorectal cancer patients without type 2 diabetes mellitus group were 322 cases (53.8%), 40 to 59 years were 208 cases (34.7%), <40 years were 69 cases (11.5%). The proportion of Age ≥ 60 years in colorectal cancer patients with type 2 diabetes group was higher than that in colorectal cancer patients without type 2 diabetes group,there were statistically significant (P<0.05).In colorectal cancer patients with type 2 diabetes group,Distribution of lesions in the rectum were 151 cases (61.6%), in colon were 94 cases (38.4%);In colorectal cancer patients without type 2 diabetes group,Distribution of lesions in the rectum were 323 cases (53.9%), in colon were 276 cases (46.1%), the difference between the two groups was statistically significant (P<0.05). There were 17cases(6.9%) of Dukes' A in colorectal cancer with type 2 diabetes, Dukes' B 76 cases(31.1%) and Dukes' C+D 152 cases(62.0%). There were 64 cases(10.7%) of in Dukes' A in colorectal cancer with type 2 diabetes, Dukes' B 221 cases(36.9%) and Dukes'C+D 314 cases(52.4%). Colorectal cancer patients with type 2 diabetes had a higher rate of in Dukes' C+D; two groups were statistically different (P=0.011). Conclusion Type 2 diabetes is a risk factor for colorectal cancer. Type 2 diabetes with colorectal cancer mainly occurred in ≥ 60 years of age; lesion mainly distributes in rectum; the prognosis of cancer is poor.