Effect of irbesartan and hydrochlorothiazide on blood pressure variability and left ventricular hypertrophy in patients with essential hypertension
Jing Chen
Li Jie
Fu Tao
Chen Jie
Chen Hong
Abstract：Objective To observe the effect of irbesartan hydrochlorothiazide tablet on variability of blood pressure and left ventricular hypertrophy in the patients with light and midrange hypertension. Methods Before the therapeutic course with irbesartan hydrochlorothiazide tablet, oral drugs were stopped in all 92 patients with hypertension for two weeks. Variability of blood pressure and left ventricular mass(LVM) with dynamic 24- hour blood pressure and echocardiography were observed in these patients before and therapeutic course. Results After treatment with oral administration of irbesartan hydrochlorothiazide tablet for 8 weeks, 24 h average systolic blood pressure (SPB) [(151±11)mmHg(1 mmHg=0.133 kPa)vs (126±10)mmHg] and 24 h SPB variability[(14.8±3.6)mmHg vs (9.7±2.8) mmHg], 24 h average diastolic blood pressure (DBP) [(96±8)mmHg vs (74±7)mmHg]and 24 h DBP variation[(12.9±3.1)mmHg vs (8.6±2.4)mmHg] were significantly decreased(P<0.05), LVM[(242±40)g vs (223±20)g]was also significantly decreased(P<0.05). Conclusion Irbesartan hydrochlorothiazide can control the blood pressure, and it can also significantly reduce the variability of blood pressure and improve ventricular reconstitute.
Keywords：Iirbesartan hydrochlorothiazideBlood pressure variabilityLeft ventricular hypertrophy
Publication Date：2014-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 303-305 )