Dynamic changes of molecular markers of pre-thrombotic state after percutaneous coronary intervention in coronary heart disease patients complicated with hypertension
Ma Jianlin
Ma Lining
Li Bin
Zhang Jiaming
Li Dazhu
Wu Zhong
Chen Guanliang
Wang Sheng
Zhang Jingwen
Lin Jin
Wang Wei
Abstract：Objective To observe the changes of molecular markers of pre-thrombotic state in coronary heart disease (CHD) patients complicated with hypertension (HBP) undergoing percutaneous coronary intervention (PCI). Methods Thirty-two cases with CHD(group A) and 38 cases with CHD and HBP (group B) underwent PCI; molecular markers of pre-thrombotic state were measured before and 20 minutes, 24 hours, 7 days after PCI. The patients were followed up regarding restenosis of the coronary arteries after PCI. Results Compared to before PCI, there were significant changes of von willedrand factor(vWF), coagulation factor Ⅷ antigen(Ⅷ:Ag), antithrombinⅢ(ATⅢ), the plasma platelet granule membrane protein 140 (GMP140), protein C, thrombin activity(F.Ⅱa), plasma fibrinogen(Fbg), serum plasminogen(Plg), the plasma levels of tissue type plasminogen activator(t-PA), plasminogen activator inhibitor(PAI), D-Dimer [(94±34)%,(89±26)%,(188±31)mg/L,(20±5)μg/L, (0.58±0.17)kU/L,(5.6±1.3)g/L,(162±45)mg/L,(0.38±0.09)kIU/L,(0.48±0.13)kAU/L,(0.89±0.28)mg/L, respectively, P<0.05 or P<0.01] 20 min after PCI, and vWF, protein C, Fbg, Plg, PAI, D-Dimer [(75±20)%,(3.5±0.8)mg/L,(5.3±1.1)g/L,(167±43)mg/L,(0.43±0.11)kAU/L,(0.78±0.19)mg/L, respectively, P<0.05 or P<0.01] 24 h after PCI in group A. Compared to before PCI, there were significant changes of vWF, Ⅷ:Ag, ATⅢ, GMP140, protein C, F.Ⅱa, Fbg, PAI, D-Dimer 20 min, 24 h, 7 d after PCI in group B[(135±37)%,(128±33)%,(88±19)% vs (70±18)%;(120±30),(99±24),(88±22)% vs (77±20)%; (157±34),(161±31),(164±33)mg/L vs (187±33)mg/L;(23±7),(22±6),(20±4)μg/L vs (17±4)μg/L;(2.2±1.1),(2.2±0.7),(2.5±0.8)mg/L vs (3.0±1.1)mg/L;(0.79±0.19),(0.74±0.18),(0.69±0.16)kU/L vs (0.61±0.16)kU/L;(6.6±1.7),(6.4±1.8),(6.1±1.7)g/L vs (5.2±1.2)g/L;(0.68±0.15),(0.66±0.15),(0.57±0.18)kAU/L vs (0.47±0.15)kAU/L; (1.22±0.34),(1.10±0.30),(0.94±0.22)mg/L vs (0.68±0.18)mg/L; P<0.05 or P<0.01]. Conclusions There are significant changes molecular markers of pre-thrombotic state in CHD patients after PCI, particularly among the patients complicated with HBP. There is a significant pre-thrombotic state in CHD patients after PCI, which might be promoted by HBP.
Keywords：Coronary heart diseaseHypertensionPercutaneous coronary interventionMolecular markers of pre-thrombotic state
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 289-293 )