Clinical research of catheter-directed intra-arterial thrombolysis therapy with recombinant human tissue-type plasminogen kinase derivatives reteplase
Hou Hongjun
Xu Zushan
Abstract：Objective To investigate the value of the recombinant human tissue-type plasminogen kinase derivatives reteplase in the treatment of lower extremity arterial occlusive disease by catheter-directed intra-arterial thrombolysis operation.Methods Forty-six lower extremity arterial occlusive disease patients (occlusive vascular 54 section) were collected with reteplase and a variety of Catheter-directed thrombolytic techniques; according to the extent of patency by angiography,the percutaneous transluminal angioplasty (PTA) was carried out; for some segments stenosis degree ＞60％ or dissections,the stent placement as a combined therapy was applied.When the intervention was completed,the color Doppler ultrasound or CT angiography (CTA) was reviewed to evaluate clinical efficacy after 3 months,6 months and 12 months respectively.It was showed that vascular lumen residual stenosis was ＜ 30％ by angiography after the occlusion released.Results Endovascular treatment was successful.Fifty-two section of endovascular occlusion treatment was successful,surgical success rate was 96.3％.Thirty-three section of occlusive vascular were opened after thrombolysis operation,the patency rate was 61.1％.After 3 months,6 months and12 months,patency rates were 89.1％ (41/46),87.0％ (40/46)and 82.6％ (38/46).Distal arterial embolization in three cases (6.5 ％) was discovered by intraoperative angiography.Puncture site hematoma occurred in 2 patients (4.3％ was self-absorbed).Conclusion The catheter-directed intra-arterial thrombolysis therapy with rateplase has an important role in lower extremity arterial occlusive disease.
Keywords：Recombinant human tissue-type plasminogen kinase derivativesReteplaseLower extremity arterial occlusive diseaseCatheter-directed intra-arterial therapy
Publication Date：2014-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 217-220 )