Clinical observation of radiotherapy combined with nedaplatin and hyperthermia in the treatment of advanced esophageal carcinoma
Cai Jundong
Liu Jing
Zeng Shuchao
Cui Yanli
Li Jinghai
Wang Ruifang
Abstract：Objective To observe the effect of three-dimensional conformal radiotherapy in combination with weekly dose of nedaplatin and extracorporeal high-frequency hyperthermia on advanced esophageal carcinoma.Methods Ninety-nine cases of patients with advanced esophageal carcinoma in the third hospital of Chengde from January 2010 to May 2012 were selected.Ninety-nine cases of advanced esophageal carcinoma were randomly divided into the standard chemoradiotherapy group (33 cases),the experimental chemoradiotherapy group(33 cases)and the experimental hyperthermochemoradiotherapy group (33 cases).One month after treatment,the response rate and recent adverse effects and one-year survival rate were evaluated.Results Response rate of the standard chemoradiotherapy group was 66.7％ (22/33).Response rate of the experimental chemoradiotherapy group was 63.6％ (21/22).Response rate in the experimental hyperthermochemoradiotherapy group was 90.9％ (30/33).The experimental hyperthermochemoradiotherapy group was statistically different from other groups (P ＜ 0.05).One year survival rate of the standard chemoradiotherapy group was 54.5％ (18/33).One year survival rate of the experimental chemoradiotherapy group was 57.6％ (19/33).One year survival rate of the experimental hyperthermochemoradiotherapy group was 81.8％ (27/33).The experimental hyperthermochemoradiotherapy group was statistically different from other groups (P ＜ 0.05).The experimental hyperthermochemoradiotherapy group dysphagia reduce accounted for 87.9％ (29/33),which was higher than other groups (P ＜ 0.05) ; Weight gain accounted for 78.8％ (26/33)and KPS score gain accounted for 81.8％ (27/33).The esophagitis incidence of the experimental hyperthermochemoradiotherapy group was 81.8％ (27/33),which was higher than that of the standard chemotherapy group (P ＜ 0.05).The incidence rate of nausea and vomiting of the standard chemotherapy group was statistically different from other groups (P ＜ 0.05).Conclusion The treatment of three-dimensional conformal radiotherapy in combination with extracorporeal high-frequency hyperthermia is effective for advanced esophageal carcinoma.
Keywords：Esophageal neoplasmsThree-dimensional conformal radiotherapyNedaplatinDrug therapycombinationHyperthermiainduced
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 203-207 )