Comparison of repeated drug eluting stent for treatment of early and late in-stent restenosis after drug eluting stent implantation
Abstract：Objective To compare the efficiency and safety of repeated drug eluting stent (DES) for treatment of early and late DES in-stent restenosis(ISR).Methods Patients treated with repeated DES for DES ISR in Beijing anzhen hospital between October 2008 and December 2011 were followed up.All lesions were divided into early ISR group(within 1 year) (43 cases)and late ISR group (in ＞ 1 year) (64 cases) by the period ISR occurring after initial DES implantation.Major adverse cardiovascular events (MACE) including all-cause death,myocardial infarction and clinical target lesion revascularization (TLR) were the primary endpoints.Results There were not differences between early ISR group and late ISR group in clinical and angiographic characteristics(P ＞0.05),but the rate of diabetes mellitus in early ISR group was lower than that in late ISR group [22.7％ (10/44) vs 42.9％ (27/63),P ＜ 0.01].The incidence rates of TLR and MACE in early ISR group were higher than those in late ISR group [12.7％ (8/63) vs 43.2％ (19/44) ; 15.9 (10/63) ％ vs 47.7％ (21/44) ; all P ＜0.01].The risk factors of TLR by a Logistic regression model showed that the significant predictor of TLR was early ISR (OR =6.47,95％ CI:2.26-18.50; P ＜ 0.01) after implantation of repeated DES.Conclusion Repeated DES implantation is safe and effective for treatment of late ISR patients.
Keywords：Drug eluting stentStent restenosisearlylateRepeated revascularization
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 156-159 )