Combination of nifedipine and captopril treating essential hypertension
Zhai Dongli
Zhong Jiuchang
Abstract：Objective To investigate combined therapeutic effect of nifedipine and captopril treating essential hypertension.Methods One hundred and two patients of essential hypertension were divided into treatment group and control group,with 51 cases in each group.The control group had captopril 20 mg; the treatment group received captopril 20 mg and nifedipine 30 mg pertime for 8 weeks.Results The total effective rate of treatment group was 88.3％ (45/51),which was significantly higher than that of the control group[72.5％ (37/51)] (P ＜ 0.05).After treatment,systolic blood pressure,diastolic blood pressure and heart rate in control groupwere lower than those of before treatment [respectively (137 ± 8) mmHg vs (153 ± 9) mmHg,(92 ± 7) mmHg vs (97 ±6) mmHg,(77 ±6) beats/min vs (87 ± 6) times/min] ; after treatment systolic blood pressure,diastolic blood pressure,heart rate in treatment group were lower than those of before treatment [(129 ± 7) mmHg vs (153±10) mmHg,(89 ±6) mmHg vs (97 ±6) mmHg,(75 ± 5) beats/min vs (86 ± 6) times/min],the differences were statistically significant (P ＜ 0.05).Before and after treatment in the control group,the blood serum urea nitrogen(BUN),creatinine (Cr) and β32-microglobulin were respectively (6.8 ± 0.9) mmol/L,(6.2 ±0.9) mmol/L,(107±13) mmol/L,(104±12) mmol/L,(687±81) μg/L,(427 ±55) μg/L,while in the treatment group they were (6.6 ± 0.6) mmol/L,(6.0 ± 0.7) mmol/L,(106 ± 12) mmol/L,(102 ± 12) mmol/L,(683 ±76) μg/L,(414 ±53) μg/L.The BUN,Cr and β2-microglobulin decreased after treatment.Conclusion The combined therapeutic effect of nifedipine and captopril have a good curative effect on essential hypertension.
Keywords：Essential hypertensionNifedipineCaptoprilHeart rateAngiotensin
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 153-155 )