Association of the growth differentiation factor-15 with chronic heart failure in coronary heart disease patients
Zhu Zhidong
Sun Tao
Abstract：Objective To explore the diagnostic value of the growth differentiation factor-15 (GDF-15) level in plasma and its relationship with chronic heart failure in coronary heart disease patients.Methods Totally 98 coronary heart disease patients with chronic heart failure(myocardial infarction group) or without chronic heart failure(coronary artery disease group) were enrolled in the study.Plasma GDF-15 level was determined with enzyme linked immunoadsorbent assay method and compared with 87 normal coronary artery disease patients (control group).Results GDF-15 average level in myocardial infarction group,its various subgroups of cardiac function classification (New York Heart Association Ⅰ,Ⅱ,Ⅲ,Ⅳ) and coronary artery disease group were significant higher than those in control group[1 622(888,1 995),983 (808,1 501),1 614(810,1 825),1 940(1 837,2 063),3 905 (3 690,4 019),945 (856,1 000) ng/L vs 798 (728,873) ng/L] (P ＜ 0.05).N-terminal pro-brain natriuretic peptide (NT-proBNP) average level in myocardial infarction group and its various subgroups of cardiac function classification (New York Heart Association Ⅰ,Ⅱ,Ⅲ,Ⅳ) were significant higher than control group [564 (158,857),233 (105,552),278 (133,716),790 (636,1 490),4 665 (3 712,5 442) ng/L vs 121 (108,134) ng/L] (P ＜0.05).Mter adjustment,plasma GDF-15 level was found to be related to the proved clinical maker NT-proBNP (r =0.861,P ＜ 0.01),it was negative correlated with left ventricular ejection fraction(r =-0.936,P ＜ 0.01).The receiver operating characteristic curve of the GDF-15 level and NT-proBNP level was constructed and the area under concentration for continuous untransformed GDF-15 was 0.804,0.795 (P ＜ 0.01).Best critical value of GDF-15 was 1 086.38 ng/L,the diagnosis of chronic heart failure sensitivity was 72.4％,specificity was 93.6％.Conclusion GDF-15 can be used as a new prognostic biomarker of chronic heart failure.
Keywords：Coronary heart diseaseChronic heart failureGrowth differentiation factor-15N-terminal pro-brain natriuretic peptideAssociation analysisReceiver operating characteristic curve
Publication Date：2014-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 149-153 )