Clinical study of compound alverine citrate in treating chronic non-atrophic gastritis

Huang Zhenpeng; Liang Zhonghui; Li Jinli; Ye Jiaxiang

doi:10.3760/cma.j.issn.1673-4777.2014.01.021

Abstract：Objective To discuss the effect of compound alverine citrate treating chronic non-atropmc gastritis and related adverse reaction.Methods Totally 124 cases of chronic non-atrophic gastritis were divided into observation group and control group.Observation group received rabeprazole and compound alverine citrate; control group received rabeprazole and mosapride citrate.All groups received drugs for 2 weeks.Each symptom scores and the total symptom score were evaluated and the efficacy was assessed according to the symptom score and the changes of symptom score.Results After four weeks treatment,each symptom score was decreased significantly in the observation group(P ＜0.05) ; the symptom score was significantly lower than that in the control group.Symptoms scores in abdominal pain,bloating,belching of observation group were reduced significantly compared with control group [(0.9 ± 0.4) scores vs (1.6 ± 0.5) scores,(0.8 ± 0.4) scores vs (2.3 ± 0.7) scores,(0.80 ± 0.19) scores vs (1.13 ± 0.44) scores] (P ＜ 0.05).And there were no significant difference in acid reflux and abdominal between two groups (all P ＞ 0.05).After treatment,two groups' total score of symptoms were decreased; the total symptom score in observation group was significantly lower than that in the control group [(4.7 ± 1.2) scores vs (7.6 ± 1.2) scores] (P ＜ 0.05).The efficiency and the total effective rate in abdominal pain,abdominal distention,acid regurgitation,belching,epigastric discomfort and other symptoms of observation groupwere higher than those in the control group [91.7％ (55/60) vs 82.8％ (48/58),94.8％ (55/58) vs 74.1％ (43/58),90.3 ％ (28/31) vs 77.4％ (24/31),91.1％ (41/45) vs 72.2 ％ (26/36),89.8 ％ (53/59) vs 83.0％ (49/59),95.0％ (57/60) vs 91.5％ (54/59)] (all P ＜ 0.05).There was no significant difference in incidence of related adverse reaction between two groups (P ＞ 0.05).Conclusion Compound alverine citrate treating chronic non-atrophic gastritis is high efficiency and safe.