Correlations between B-cell-specific moloney leukemia virus insert site 1 expression and clinic-pathological factors and prognosis of patients with lung adenocarcinoma
Zhang Xueyan
Wang Huimin
Lou Yuqing
Jin Bo
Han Baohui
Abstract：Objective To detect the B-cell-specific moloney leukemia virus insert site 1 (Bmi1)expression in lung adenocarcinoma tissues,and to analyze its relevance to the metastasis,chemotherapeutic effect and prognosis in lung adenocarcinoma patients.Methods The Bmi1 expression in lung adenocarcinoma tissues was detected by immunohistochemical methods.The relationship between Bmi1 expression and clinical pathological indicators was examined by chi-square test.The survival rate was calculated by Kaplan-Meier survivorship curve.The relevance between the indicators and the patient survival was estimated by COX analysis.Results Among the 126 lung adenocarcinoma tissue samples,Bmi1 positive cells were found in 91 tissues and the positive rate was 57.1％.Bmi1 expression was closely related to the metastasis and chemoresistance in lung adenocarcinoma patients (P =0.000 or P =0.021),and it was in significant negative correlation with the disease free survival period and survival period of the patients.The results of multiple factor analysis showed that transfer,the expression of Bmi1 and the effect of chemotherapy after transfer were the independent influencing factors of the survival time[β =-6.212,1.015,0.867,respectively,and the 95％ confidence interval:0.000-0.019,1.727-4.405,1.680-3.372,respectively,and all P =0.000].Conclusion Bmi1 expression is related to the metastasis and chemoresistance in lung adenocarcinoma patients and indicates a poor prognosis.
Keywords：Lung neoplasmsB-cell-specific moloney leukemia virus insert site 1Prognosis
Publication Date：2014-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 32-36 )