Expression of bronchioalveolar stem cells-related indicators in normal lungs and lung adenocarcinoma
Shao Jianwei
Lu Yiming
Han Baohui
Dong Qianggang
Zheng Biqiang
Zhang Xueyan
Abstract：Objective To detect the bronchioalveolar stem cells (BASC)-related indicators expression in normal lung tissues and lung adenocarcinoma tissues by immunofluorescence method in order to confirm the presence and location of BASC in human.Methods Totally 30 cases normal human lung tissues and 30 cases human lung adenocarcinomas tissues were detected with the expression of synthesizing protein complex,clara cell secretion protein and OCT4 with immunofluorescence method.Results The BASC-like stem cells were detected in normal lung tissue and they were located in bronchiolar-alveolar duct junction.The cancer stem cells with BASC phenotype were also detectable in lung adenocarcinoma and the self-renewal regulatory gene OCT4 expression in these cells.Conclusion BASC-related indicators can express in normal lung tissues and lung adenocarcinoma tissues,which reveals that human lung adenocarcinoma may originate from the malignant transformation of BASC and share the same phenotype as BASC.
Keywords：Bronchioalveolar stem cellsCancer stem cellsLung adenocarcinoma
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 27-31 )