Effect of pentazocine on postoperative intravenous analgesia in patients undergoing off-pump coronary artery bypass grafting operation
Zhao Wendu
Zhang Liang
Lu Jiakai
Cheng Weiping
Abstract：Objective To observe the analgesic effect of pentazocine after off-pump coronary artery bypass grafting operation.Methods All 64 elective male patients undergoing off-pump coronary artery bypass grafting operation were randomized divided into fentanyl group(group F,n =16) and pentazocine group P1 (n =16),group P2(n =16) and group P3(n =16) group.In group F,2 mg fentanyl was diluted into 200 ml with saline.Each group had continuously intravenous infusion at the speed of 2 ml/h.Visual analogue scale (VAS),Ramsay sedation score,total analgesic comfortable score,adverse reactions and additional analgesics were recorded at 4,8,12,24,36,48,72,96 h after the analgesia pump was connected to patient.Results VAS score of group P1 [(2.4 ± 1.2),(3.2 ± 1.8) scores] was higher than that of other groups at 8 h and 12 h (P ＜ 0.05).The analgesic excellent rate of group P1 was 68.7％ (11/16) and the analgesic excellent rate of pentazocine group was higher than fentanyl group[100.0％ (16 cases) vs 87.5％ (14 cases),P ＜ 0.05].Conclusion Pentazocine can produce reliable postoperative analgesia for patients undergoing after off-pump coronary artery bypass grafting operation and the rate of adverse reactions is lower than fentanyl.
Keywords：Off-pump coronary artery bypass grafting operationPentazocineAnalgesia
Publication Date：2014-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )