Analysis on the changing trend of fasting plasma glucose and risk factors for post-transplant diabetes mellitus after heart transplantation
Shi Xiujin
Wei Guoyi
Zhu Mu
Lin Yang
Bai Yuguo
Zhou Yang
Abstract：Objective To investigate the fluctuation of fasting plasma glucose (FPG),incidence and presence of risk factors for post-transplant diabetes mellitus(PTDM) after heart transplantation.Methods The clinical data of 66 patients undergoing heart transplantation and surviving for more than 3 months were retrospectively analyzed.According to preoperative FPG levels,patients were divided into three groups:preoperative diabetes mellitus(Pre-DM,12 cases),impaired fasting glucose (IFG,11 cases) and normal fasting glucose (NFG,43 cases).The changing trend of FPG level was observed.For 54 non-diabetes patients before transplantation,the prevalence and different outcomes of PTDM according to FPG after transplantation were analyzed.Univariate analysis and logistic regression for multivariate analysis were performed to identify the risk factors associated with development of PTDM.Results FPG in pre-transplant,1 week post-transplant,6-month post-transplant,1-year posttransplant in three groups were respectively:[Pre-DM group:(8.5 ± 1.9),(10.3 ± 2.7),(7.6 ± 2.4),(7.0 ± 1.7) mmol/L; IFG group:(6.7 ± 1.7),(10.2 ± 3.8),(6.3 ± 1.2),(6.1 ± 1.0) mmol/L; NFG group:(4.6 ±0.6),(8.2 ±3.9),(5.9 ± 2.0),(5.7 ± 1.1) mmol/L],patients' FPG within 1-week post-transplant were higher than those pre-transplant,there was statistically significant difference among the three groups (P ＜ 0.05).Of the 54 patients,20 cases developed PTDM,including 12 cases (60.0％) with persistent PTDM and 8 cases (40.0％) turning into NFG or IFG.Univariate analysis showed that body mass index,preoperative triglyceride levels and cyclosporin A plasma concentration were risk factors; multivariate logistic regression analysis identified the following predictive factors for the development of PTDM:preoperative triglyceride levels (OR =6.373,P =0.016) and cyclosporin A plasma concentration (OR =6.352,P =0.016).Conclusions PTDM will not be permanent and may recover to NFG and IFG in the course of the disease.Preoperative triglyceride levels and cyclosporin A plasma concentration are risk factors for the development of PTDM during follow-ups.
Keywords：Heart transplantationPost-transplantation diabetes mellitusFasting plasma glucoseRisk factors
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 5-9 )