Changes of ambulatory blood pressure in resistant hypertension patients with abnormality of glycometabolism
Ma Linlin
Yu Zhenqiu
Qu Fengxue
He Lei
Abstract：Objective To detect the effects of the glycometabolism abnormality on the ambulatory blood pressure in patients with resistant hypertension.Methods Totally 144 patients with resistant hypertension had 24 h ambulatory blood pressure monitoring and oral glucose tolerance test (OGTT).According to the results of OGTT,the patients were divided into three groups:normal glucose tolerance (NGT)(53 cases),impaired glucose tolerance(IGT) (43 cases),diabetes mellitus (DM)(48 cases).Results The temporal rhythm of 24 h blood pressure of the 144 resistant hypertension patients with glycometabolism abnormality was disturbed.The incidence of non-dipper rhythm of blood pressure in the patients with IGT and DM increased significantly compared with those in NGT group[79.1％ (34/43),83.3％ (40/48) vs 69.8％ (37/53) ; 81.4％ (35/43),70.8％ (34/48) vs 66.0％ (35/53)] (P ＜ 0.05).The patients with DM had the highest incidence of non-dipper rhythm of systolic blood pressure[83.3％ (40/48)].Nocturnal hypertension among the three groups showed no significant difference (P ＞ 0.05).24 hours diastolic blood pressure load in IGT group were higher than NGT group and DM group [40.8 (16.9,73.1) mmHg vs 30.4 (2.9,50.2),23.3 (1.3,43.7) mmHg] (P ＜ 0.05).24 hours systolic blood pressure,daytime systolic blood pressure,nighttime systolic blood pressure in NGT patients were significantly lower than those in IGTgroupandDM group[(126±13)mmHgvs (133±17),(133±12)mmHg; (128±12)mmHg vs (135±18)mmHg,(134±12)mmHg; (122±16)mmHg vs (131 ±19)mmHg,(130±16)mmHg](P＜ 0.05).The 24 hours diastolic blood pressure,daytime diastolic blood pressure,nighttime diastolic blood pressure,24-hour mean arterial pressure,nighttime mean arterial pressure in IGT group were higher than those in NGT group and DM group[(85±12)mmHgvs (80±11)mmHg,(76±12)mmHg; (87±13)mmHg vs (82±11)mmHg,(78 ± 13) mmHg; (83 ± 14)mmHg vs (76 ± 12) mmHg,(72 ± 12) mmHg; (101 ± 13) mmHg vs(95 ± 10) mmHg,(95 ± 10) mmHg; (99 ± 14)mmHg vs (92± 12) mmHg,(92± 12) mmHg; and daytime systolic blood pressure,nighttime systolic blood pressure were higher than DM group (P ＜ 0.05).24-hour mean pulse pressure,daytime mean pulse pressure,nighttime mean pulse pressure in DM group were slightly higher than those in NGT group and IGT group [(57 ± 13) mmHg vs (46 ± 10) mmHg,(48 ± 10) mmHg ; (56 ± 12) mmHg vs (46 ± 10) mmHg,(48 ± 10)mmHg;(58±14)mmHgvs (46±11)mmHg,(48±12)mmHg](P＜0.05).Conclusion Circadian blood pressure rhythm is damaged in the resistant hypertension patients with abnormality of glycometabolism.
Keywords：Hypertension,resistantDiabets mellitusImpaired fasting glucoseAmbulatory blood pressure
Publication Date：2014-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )