Effect of age on pharmacodynamics of cisatracurium in TIVA
GAO Fei-yu
XU Hui-qing
Abstract：Objective To evaluate the effect of age on pharmacodynamics of cisatracurium in total intravenous anesthesia.Methods Foay patients with lumbar vertebra internal fixation surgery under total intravenous anesthesia were divided into group Ⅰ and Ⅱ with 20 cases in each group.Under TOF stimulation monitoring,cisatracurium 0.15 mg/kg was infected and tracheal intubation was performed when TOF being zero.When T1 restored to 5％,cisatracurium 0.05 mg/kg(injected within 5 s each time) was injected at irregular intervals.The intubation conditions and the pharmacodynamcs of cisatracurium were evaluated.Results Intubation conditions of the onset time and recovery index were not significantly different between the two groups.The clinical effective time and recovery to 25％ and 75％ time was(42 ±5),(52 ±7),(66 ± 13)min,and group]Ⅱ was(40 ±5),(49 ±5),(62 ± 11) min,the group Ⅰ was longer than group Ⅱ.Each clinical effective time of the four times additional drugs in group Ⅰ was longer than that in group Ⅱ.There was no notable difference on that between the two groups.Cisatracurium average dosage was less in group Ⅰ [(3.5 ± 1.3) μg/(min · kg)] than that in group Ⅱ [(4.6 ± 1.5) μg/(min · kg)] (P ＜ 0.05).Conclusion In TIVA in elderly patients the cisatracurium dosage reduces,recovery process is still longer compared to young adults,but long-term repeated additional medication almost leave no accumulation in the body,which can be safely applied.
Keywords：PharmacodynamicsCisatracuriumElderlyIntravenous anesthesia
Publication Date：2013-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 54-56 )