Pulmonary tumourlet: a clinicopathological observation
WANG Xiao-bing
ZOU Wei
YI Zhi-jun
WU Hui-ru
LI Yong-sheng
Abstract：Objective To investigate clinicopathological characteristics and differential diagnosis of pulmonary tumourlet.Methods One case of pulmonary tumourlet was studied by light microscopy,histochemistry,and immunohistochemistry,and reviewed relevant literatures to analyze the clinical,morphological,immunohistochemical features,treatment and prognosis of the pulmonary tumourlet.Results The patient was a 61 years old man.The pulmonary tumourlet was characterized histologically by multi-focal nodules and most were displayed only under microscopy.The tumourlet cells were arranged in clusters and foci of fascicles which were situated in the surrounding bronchial wall and bronchioles adjacent to bronchiectatic lesion,or in the scar tissues.The tiny tumours were consisted of a relatively uniform population small ovoid cells.Their nuclei were circular,oval or spindle.Mitotic activity and necrosis were absent.Intensive positive immunostaining for cytokeratin,neuron speicfic enolase,synaptophysin,chromogranin A,5-hydroxytryptamine,gastrin and calcitonin were detected.The cells were strongly argyrophilic on Grimelius staining.Conclusions The pulmonary tumourlet is a very rare tumour with no specific imaging features and examination,so it may be the early stage of typical carcinoid.The diagnosis is based on immunohistochemical staining.It should be differentiated from other lesions of the bronchial,including diffuse idiopathic pulmonary neuroendoefine cell hyperplasia,carcinoid carcinoma,small cell carcinoma,minute pulmonary meningioma-like nodule and paraganglioma.For the treatment of the pulmonary tumourlet,surgical resection has a good prognosis.
Keywords：Lung neoplasmsTumourletImmunohistochemistry
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 7-8 )