Clinical research of inhalating pulmonary surfactant in the prevention and treatment of respiratory distress syndrome
HU Ling-ying
WANG Li
SUN Xiao-fang
XU Fang-fang
Abstract：Objective To observe the effect of aerosol inhalating the pulmonary surfactant in treatment of respiratory distress syndrome.Methods Fifty-two cases of neonatal respiratory distress syndrome were randomly divided into inhalation group and intubation group,each group had 26 cases.Inhalation group were given lung surface active substances under oxygen driving,intubation group used endotracheal intubation drip lung surface active material.The clinical manifestation,blood gas analysis and its complications of two groups were compared before and 6,24 h after treatment.Results Clinical performance improved significantly after 6 hours from applicating pulmonary surfactant.The results of inhalation of children with blood gas analysis were same with the results of intubation(P ＞ 0.05).Clinical performances were also returned to normal after 24 hours.The results of inhalation of children with blood gas analysis were the same with the results of intubation(P ＞ 0.05).One case(3.8％) had lung infection in children who inhaled pulmonary surfactant.Nobady had pneumothorax and atelectasis in children who inhaled pulmonary surfactant.Eight cases (30.8％) had lung infection in children who instiled pulmonary surfactant.Two cases (7.7％) had pneumothorax and 1 case(3.8％) had aelectasis in children who were injected from intubation the pulmonary surfactant.Conclusions Aerosol inhalating pulmonary surfactant has markedly effect in the treatment of respiratory distress syndrome,it can effectively improve lung function and reduce complications.
Keywords：Respiratory distress syndromeAerosol inhalatingPulmonary surfactant
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 5-6 )