Effects of yeast polysaccharides on immune function
GE Shu-zhi
LIU Hui-ying
AN Yu-ping
ZHAO Ting-xue
LIU Yin-hua
WANG Yue
ZHANG Qing-bo
Abstract：Objective To investigate the effects of yeast polysaccharides on immune function of mice; to provide a new product for food additive industry.Methods In vitro,spleen lymphocytes of mouse were separated,extracted and cultured with yeast polysaccharides (0.00,0.25,0.50,1.00,2.00,4.00 g,/L) for 3,6,9 d.Then the proliferation and secretion amount of inter/eukin 2(IL-2) were detected and cell phenotypes were analyzed.In vivo,carps of the experimental group were fed with yeast polysaccharides.The feeding time was recorded and compared.Results The proliferation of spleen lymphocytes cultured with 0.50,1.00,2.00,4.00 g/L yeast polysaccharide for 3,6,9 d was significantly higher than that of 0.00 g/L (P ＜ 0.05) ; the secretion of IL-2 in 0.25,0.50,1.00,2.00,4.00 g/L yeast polysaccharid for 9 d was notably increased compared with the 0.00 g/L yeast polysaccharid [(9.4±1.3),(13.4±1.2),(13.2 ±1.2),(15.6±3.6),(10.8 ±1.3)μg/L vs (7.3 ± 1.1)μg/L,P＜0.05];when yeast polysaccharid was 2.00 g/L for 6 d,the amount of T/B cells were (9.14 ± 0.31) ％,(4.47 ± 0.55) ％,which was significantly higher than that of 2.00 g/L yeast polysaccharid [(5.01 ± 0.74) ％,(2.73 ± 0.22) ％,P ＜0.01].Yeast polysaccharid enhanced feeding speed of carps [(10 ± 5) min vs (23 ± 13) min,P ＜ 0.01].Conclusion Yeast polysaccharid can be used as food additives to enhance immune function and appetite.
Keywords：Food additivesYeast polysaccharideCell proliferationCell subsets
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 1738-1739 )