Effect of treatment of asthma complicated by gastroesophageal reflux disease with seretide combined esomeprazole and mosapride
WANG Hai-yan
SONG Ke
Abstract：Objective To observe the effectiveness of the treatment of asthma complicated with gastroesophageal reflux disease (GERD) by seretide combined esomeprazole and mosapride.Methods This was a prospective randomized controlled trial.One hundred patients with asthma complicated by GERD were randomly divided into a treatment group (group A) and the control group (group B).Group A were treated by conventional antiasthmatic (seretide) therapy combined with anti-esophageal reflux acid-suppressing drug (esomeprazole) and motility drug (mosapride).Group B were only treated by conventional antiasthmatic (seretide).The effects of treatment were analysis between groups.Results The effective rate of observation group was 92.0％ (46/50) and the effective rate was 44.0％ (22/50) in the control group; the difference was statistically significant (P ＜ 0.01).Observation group lung function (including forced expiratory volume in one second and forward voice channel) was significantly improved after treatment (P ＜ 0.01) ; the observation group and control group had statistically significant differences in pulmonary function after treatment (P ＜ 0.01).Conclusion Concurrent treatment of GERD asthma,asthma medication plus anti-reflux acid-suppressing drugs and motility drugs can increase the effective rate.
Keywords：AsthmaGastroesophageal reflux diseaseSeretideEsomeprazoleMosapride
Publication Date：2013-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 1724-1725 )