Effect of limbs ischemia reperfusion on lung injury of diabetes
WANG Xiao-yan
Abstract：Objective To investigate the effect of limbs ischemia reperfusion on lung injury of diabetes.Methods Totally 20 cases of diabetic patients and non-diabetic with lower limb operation were selected.Alveolar arterial oxygen pressure,oxygenation index (OI),and interleukin 6 (IL-6) concentration of different point of time (T0-T5) were recorded.Results After the release of the tourniquet,using different surgical methods treatment.P (A-a) DO2 value increased.In diabetic group,P (A-a) DO2 was (13.3 ± 8.7),(24.1 ± 8.7) mm Hg (1 mm Hg =0.133 kPa),while non-diabetic group was (13.5 ±7.9),(18.5 ± 1.3) mm Hg in T0 and T4.Diabetic group was significantly higher than that non-diabetic group (P ＜ 0.05).The value of OI decreased in diabetic group:(430 ±34),(389 ±36),(345 ±32),(378 ±26) mm Hg,while non diabetes group was (427 ±35),(398 ±46),(370 ± 43),(407 ± 36) mm Hg in T0,T3,T4,T5.In diabetes group,OI values decreased significantly compared with the non diabetes group in T4 and T5 (P ＜ 0.05).The IL-6 concentration of diabetic group was (2.3±1.3),(6.9± 1.8),(23.1 ±7.6) and (10.1 ± 1.8) ng/L,while of non diabetes group it was (2.4 ± 1.2),(5.7 ± 1.8),(18.5 ± 7.3) and (8.9 ± 1.6) ng/L in T0,T3,T4,T5.IL-6 of T3-T5 was significantly higher than that of T0 (P ＜ 0.05).IL-6 concentration of diabetic group increased significantly higher than that in non-diabetic group at the time of T4 and T5 (P ＜ 0.05).Conclusion The application of tourniquet in lower extremity operation may induce lung injury; diabetes with tourniquet can cause more serious lung injury.
Keywords：DiabetesLimbs ischemia reperfusionLung injury
Publication Date：2013-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1721-1723 )