Application of midazolam and flumazenil in uvulopalatopharyngoplasty in anesthesia recovery period
Abstract：Objective To observe the safety and effectiveness of midazolam-flumazenil for uvula palate pharyngoplasty anesthesia in recovery period.Methods Forty cases scheduled for UPPP surgery were selected and randomly divided into midazolam group (group M,n =20) and propofol group (group P,n =20).Two groups were treated with sedation induced and nasal intubation.Intraoperative sedation was maintained in group M with midazolam 0.1-0.2 mg/(kg · h) constant speed pump; group P was given propofol 4-6 mg/kg to maintain constant speed pump.Intraoperative constant analgesic of two groups was maintained with remifentanil 0.2-0.4 μg/(kg · min) pumped.Intermittent intravenous rocuronium was maintained muscle relaxation.After surgery the patients of group M were intravenous injected of flumazenil to awake.The hemodynamic changes when entering the operating room,intubation,extubation and out of the operating room were recorded.The time of spontaneous breathing recovery,calling eye opening,extubation and OAA/S score as well as up to 5 points time were recorded; adverse reactions were recorded.Results The difference of two groups' mean artery pressure(MAP) and HR at each time point was not statistically different (P ＞ 0.05).Compared with the time entering the operating room,MAP and heart rate (HR) decreased after the induction (P ＜ 0.05) ; the difference of spontaneous breathing recovery time of two groups was not statistically different (P ＞ 0.05).Calling eye opening time [(2.9 ± 0.5) min],extubation time [(5.4 ±1.2) min] and the time to 5 points of OAA/S score [(7.0 ± 1.5) min] in group M was significantly shorter in group P [(10.1 ± 2.0) min,(12.6 ± 2.3) min,(13.6 ± 3.1) min] (all P ＜ 0.05).The incidence of restlessness/cough of two groups in recovery period was no significant different (P ＞ 0.05).Two groups did not occur sedation again and respiratory obstruction after extubation.The incidence of postoperative nausea and vomiting and intraoperative awareness was no significantly different (P ＞ 0.05).Conclusion Midazolam-flumazenil for uvulopalatopharyngoplasty' anesthesia can shorten the recovery time and improve the quality of recovery.
Keywords：MidazolamFlumazenilIntravenous anesthesiaUvula palate pharyngoplastyAwaking quality
Publication Date：2013-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1708-1710 )